ArticleMolecular biology of the cell1998
Delayed activation of the store-operated calcium current induced by calreticulin overexpression in RBL-1 cells.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 79 citations in OpenAlex.
- Activating mutations in JAK2 and CALR differentially affect intracellular calcium flux in store operated calcium entry.Cell communication and signaling : CCS · 2024Article
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- Pathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in Thrombopoiesis.International journal of molecular sciences · 2016Review
- Differential clinical effects of different mutation subtypes in CALR-mutant myeloproliferative neoplasms.Leukemia · 2016Article
- Calreticulin is a thermostable protein with distinct structural responses to different divalent cation environments.The Journal of biological chemistry · 2011Article
- Organellar calcium buffers.Cold Spring Harbor perspectives in biology · 2011Review
- Localization of TRPC1 channel in the sinus endothelial cells of rat spleen.Histochemistry and cell biology · 2005Article
- Initiation of embryonic cardiac pacemaker activity by inositol 1,4,5-trisphosphate-dependent calcium signaling.Molecular biology of the cell · 2005Article
- Calreticulin in the heart.Molecular and cellular biochemistry · 2004Article
- Store-operated Ca2+ entry: dynamic interplay between endoplasmic reticulum, mitochondria and plasma membrane.The Journal of physiology · 2003Article
- Human T-cell lymphotropic virus type 1 p12(I) expression increases cytoplasmic calcium to enhance the activation of nuclear factor of activated T cells.Journal of virology · 2002Article
- Calreticulin reveals a critical Ca(2+) checkpoint in cardiac myofibrillogenesis.The Journal of cell biology · 2002Article
- Functional specialization of calreticulin domains.The Journal of cell biology · 2001Article
- Endoplasmic reticulum in the heart, a forgotten organelle?Molecular and cellular biochemistry · 2001Review
- The Ca(2+) status of the endoplasmic reticulum is altered by induction of calreticulin expression in transgenic plants.Plant physiology · 2001Article
- The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action.The EMBO journal · 2001Article
- Complete heart block and sudden death in mice overexpressing calreticulin.The Journal of clinical investigation · 2001Article
- Changes in endoplasmic reticulum luminal environment affect cell sensitivity to apoptosis.The Journal of cell biology · 2000Article
- Cytosolic phosphorylation of calnexin controls intracellular Ca(2+) oscillations via an interaction with SERCA2b.The Journal of cell biology · 2000Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Calreticulin (CRT) is a high-capacity, low-affinity Ca2+-binding protein located in the lumen of the endoplasmic reticulum (ER) of all eukaryotic cells investigated so far. Its high level of conservation among different species suggests that it serves functions fundamental to cell survival. The role originally proposed for CRT, i.e., the main Ca2+ buffer of the ER, has been obscured or even casted by its implication in processes as diverse as gene expression, protein folding, and cell adhesion. In this work we seek the role of CRT in Ca2+ storing and signaling by evaluating its effects on the kinetics and amplitude of the store-operated Ca2+ current (ICRAC). We show that, in the rat basophilic leukemia cell line RBL-1, overexpression of CRT, but not of its mutant lacking the high-capacity Ca2+-binding domain, markedly retards the ICRAC development, however, only when store depletion is slower than the rate of current activation. On the contrary, when store depletion is rapid and complete, overexpression of CRT has no effect. The present results are compatible with a major Ca2+-buffering role of CRT within the ER but exclude a direct, or indirect, role of this protein on the mechanism of ICRAC activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.