ArticleNucleic acids research1998
Transposon Tc1 of the nematode Caenorhabditis elegans jumps in human cells.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 44 citations in OpenAlex.
- DNA transposon-based gene vehicles - scenes from an evolutionary drive.Journal of biomedical science · 2013Review
- Mariner transposons as genetic tools in vertebrate cells.Genetica · 2009Review
- The Frog Prince: a reconstructed transposon from Rana pipiens with high transpositional activity in vertebrate cells.Nucleic acids research · 2003Article
- Generating and manipulating transgenic animals using transposable elements.Reproductive biology and endocrinology : RB&E · 2003Review
- Heterologous transposition in Ustilago maydis.Molecular genetics and genomics : MGG · 2003Article
- The medaka fish Tol2 transposable element can undergo excision in human and mouse cells.Journal of human genetics · 2003Article
- In vivo transposition of Minos, a Drosophila mobile element, in mammalian tissues.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Regulated transposition of a fish transposon in the mouse germ line.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Towards integrating vectors for gene therapy: expression of functional bacteriophage MuA and MuB proteins in mammalian cells.Nucleic acids research · 2000Article
- Genome-wide insertional mutagenesis in human cells by the Drosophila mobile element Minos.EMBO reports · 2000Article
- Insertion vectors for gene therapy.Gene therapy · 2000Article
- cis and trans factors affecting Mos1 mariner evolution and transposition in vitro, and its potential for functional genomics.Nucleic acids research · 2000Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transposon Tc1 of the nematode Caenorhabditis elegans is a member of the widespread family of Tc1/mariner transposons. The distribution pattern of virtually identical transposons among insect species that diverged 200 million years ago suggested horizontal transfer of the elements between species. Thishypothesis gained experimental support when it was shown that Tc1 and later also mariner transposons could be made to jump in vitro , with their transposase as the only protein required. Later it was shown that mariner transposons from one fruit fly species can jump in other fruit fly species and in a protozoan and, recently, that a Tc1-like transposon from the nematode jumps in fish cells and that a fish Tc1-like transposon jumps in human cells. Here we show that the Tc1 element from the nematode jumps in human cells. This provides further support for the horizontal spread hypothesis. Furthermore, it suggests that Tc1 can be used as vehicle for DNA integration in human gene therapy.
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