ArticleGenetics1998
The maize regulatory gene B-Peru contains a DNA rearrangement that specifies tissue-specific expression through both positive and negative promoter elements.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- A B73×Palomero Toluqueño mapping population reveals local adaptation in Mexican highland maize.G3 (Bethesda, Md.) · 2022Article
- Identification of epigenetic regulators of a transcriptionally silenced transgene in maize.G3 (Bethesda, Md.) · 2011Article
- Genetic analysis of pigmented tuber flesh in potato.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2009Article
- Assessing the efficiency of RNA interference for maize functional genomics.Plant physiology · 2007Article
- Gene conversion between direct noncoding repeats promotes genetic and phenotypic diversity at a regulatory locus of Zea mays (L.).Genetics · 2006Article
- Transcriptionally silenced transgenes in maize are activated by three mutations defective in paramutation.Genetics · 2006Article
- Comparative structural and functional characterization of sorghum and maize duplications containing orthologous myb transcription regulators of 3-deoxyflavonoid biosynthesis.Plant molecular biology · 2006Article
- The regulatory regions required for B' paramutation and expression are located far upstream of the maize b1 transcribed sequences.Genetics · 2002Article
- Differential chromatin structure within a tandem array 100 kb upstream of the maize b1 locus is associated with paramutation.Genes & development · 2002Article
- New insights into the allosteric mechanism of human hemoglobin from molecular dynamics simulations.Biophysical journal · 2002Article
- B-Bolivia, an allele of the maize b1 gene with variable expression, contains a high copy retrotransposon-related sequence immediately upstream.Plant physiology · 2001Article
- A segmental gene duplication generated differentially expressed myb-homologous genes in maize.The Plant cell · 2000Article
- Article
- Paramutation in maize.Plant molecular biology · 2000Review
- The developmental expression of the maize regulatory gene Hopi determines germination-dependent anthocyanin accumulation.Genetics · 2000Article
- Major recent and independent changes in levels and patterns of expression have occurred at the b gene, a regulatory locus in maize.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- A mutation in the pale aleurone color1 gene identifies a novel regulator of the maize anthocyanin pathway.The Plant cell · 1999Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The B-Peru allele of the maize b regulatory gene is unusual relative to most b alleles in that it is expressed in the aleurone layer of the seed. It is also expressed in a subset of plant vegetative tissues. Transgenic maize plants containing the B-Peru gene with the first 710 bases of upstream sequence conferred the same levels of aleurone expression as nontransgenic B-Peru plants, but no pigment was made in vegetative tissues. Transient transformation assays in aleurone tissue localized the aleurone-specific promoter to the first 176 bases of the B-Peru upstream region and identified two critically important regions within this fragment. Mutation of either region alone reduced expression greater than fivefold. Surprisingly, the double mutation actually increased expression to twice the native promoter level. Our results suggest that these two critical sequences, which lie close together in the promoter, may form a negative regulatory element. Several lines of evidence suggest that the B-Peru promoter arose through the translocation of an existing aleurone-specific promoter to the b locus. Immediately upstream of the aleurone-specific promoter elements and in the opposite orientation to the b coding sequence is a pseudogene sequence with strong similarity to a known class of proteins. Our findings that novel aleurone-specific promoter sequences of the B-Peru transcription factor are found adjacent to part of another gene in a small insertion are quite unexpected and have interesting evolutionary implications.
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