ArticleGenetics1998
The mod-A suppressor of nonallelic heterokaryon incompatibility in Podospora anserina encodes a proline-rich polypeptide involved in female organ formation.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- WD-repeat instability and diversification of the Podospora anserina hnwd non-self recognition gene family.BMC evolutionary biology · 2010Article
- The fungus-specific HET domain mediates programmed cell death in Podospora anserina.Eukaryotic cell · 2007Article
- Sexual and vegetative compatibility genes in the aspergilli.Studies in mycology · 2007Article
- Comparative analysis of programmed cell death pathways in filamentous fungi.BMC genomics · 2005Article
- Fatal attraction: nonself recognition and heterokaryon incompatibility in filamentous fungi.Eukaryotic cell · 2003Review
- Identification of vib-1, a locus involved in vegetative incompatibility mediated by het-c in Neurospora crassa.Genetics · 2002Article
- Molecular genetics of heterokaryon incompatibility in filamentous ascomycetes.Microbiology and molecular biology reviews : MMBR · 2000Review
- MOD-D, a Galpha subunit of the fungus Podospora anserina, is involved in both regulation of development and vegetative incompatibility.Genetics · 1999Article
- Molecular characterization of tol, a mediator of mating-type-associated vegetative incompatibility in Neurospora crassa.Genetics · 1999Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vegetative incompatibility in fungi results from the control of heterokaryon formation by the genes present at het loci. Coexpression of antagonistic het genes in the same hyphae leads to a lethal process. In Podospora anserina, self-incompatible strains containing nonallelic incompatible genes in the same nucleus are inviable as the result of a growth arrest and a lytic process. Mutations in suppressor genes (mod genes) can restore the viability. These mod mutations also interfere with developmental processes, which suggests common steps between the incompatibility reaction and cellular differentiation. The mod-A locus, responsible for growth arrest in the self-incompatible strains, is also involved in the control of the development of female organs. The mod-A gene was isolated. An open reading frame 687 amino acids long was identified. The MOD-A-encoded polypeptide is rich in proline residues, which are clustered in a domain containing a motif that displays similarity to SH3-binding motifs, which are known to be involved in protein-protein interactions. Construction of a strain deleted for mod-A confirmed that the product of this gene involved in differentiation is a key regulator of growth arrest associated with vegetative incompatibility.
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