ReviewMolecular and cellular biochemistry1998
Insulin action in skeletal muscle from patients with NIDDM.
Review in Molecular and cellular biochemistry, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 80 citations in OpenAlex.
- The Effect of Lower Limb Combined Neuromuscular Electrical Stimulation on Skeletal Muscle Signaling for Glucose Utilization, Myofiber Distribution, and Metabolic Function after Spinal Cord Injury.International journal of environmental research and public health · 2023Trial
- Modest weight loss improves insulin action in obese African Americans.Metabolism: clinical and experimental · 2005Trial
- The dose-effect response of combined red and infrared photobiomodulation on insulin resistance in skeletal muscle cells.Biochemistry and biophysics reports · 2024Article
- Diagnosis and Non-Invasive Treatment of Obesity in Adults with Type 2 Diabetes Mellitus: A Review of Guidelines.Journal of clinical medicine · 2023Review
- Molecular and biochemical regulation of skeletal muscle metabolism.Journal of animal science · 2022Article
- The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis.Molecular metabolism · 2019Article
- Article
- Insulin action and resistance in obesity and type 2 diabetes.Nature medicine · 2017Review
- Altered gene expression and repressed markers of autophagy in skeletal muscle of insulin resistant patients with type 2 diabetes.Scientific reports · 2017Article
- Contributors to Metabolic Disease Risk Following Spinal Cord Injury.Current physical medicine and rehabilitation reports · 2016Article
- Regulation of exercise-stimulated glucose uptake in skeletal muscle.Annals of pediatric endocrinology & metabolism · 2016Review
- Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle.Advances in physiology education · 2014Review
- Skeletal muscle signaling associated with impaired glucose tolerance in spinal cord-injured men and the effects of contractile activity.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Single point mutations result in the miss-sorting of Glut4 to a novel membrane compartment associated with stress granule proteins.PloS one · 2013Article
- Amino acids influence the glucose uptake through GLUT4 in CHO-K1 cells under high glucose conditions.Molecular and cellular biochemistry · 2010Article
- TBC1D1 regulates insulin- and contraction-induced glucose transport in mouse skeletal muscle.Diabetes · 2010Article
- Sequencing, analysis, and annotation of expressed sequence tags for Camelus dromedarius.PloS one · 2010Article
- Insulin resistance in striated muscle-specific integrin receptor beta1-deficient mice.The Journal of biological chemistry · 2009Article
- Signaling mechanisms in skeletal muscle: acute responses and chronic adaptations to exercise.IUBMB life · 2008Review
- Insulin resistance and improvements in signal transduction.Endocrine · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin resistance in peripheral tissues is a common feature of non insulin-dependent diabetes mellitus (NIDDM). The decrease in insulin-mediated peripheral glucose uptake in NIDDM patients can be localized to defects in insulin action on glucose transport in skeletal muscle. Following short term in vitro exposure to both submaximal and maximal concentrations of insulin, 3-O-methylglucose transport rates are 40-50% lower in isolated skeletal muscle strips from NIDDM patients when compared to muscle strips from nondiabetic subjects. In addition, we have shown that physiological levels of insulin induce a 1.6-2.0 fold increase in GLUT4 content in skeletal muscle plasma membranes from control subjects, whereas no significant increase was noted in NIDDM skeletal muscle. Impaired insulin-stimulated GLUT4 translocation and glucose transport in NIDDM skeletal muscle is associated with reduced insulin-stimulated IRS-1 tyrosine phosphorylation and PI3-kinase activity. The reduced IRS-1 phosphorylation cannot be attributed to decreased protein expression, since the IRS-1 protein content is similar between NIDDM subjects and controls. Altered glycemia may contribute to decreased insulin-mediated glucose transport in skeletal muscle from NIDDM patients. We have shown that insulin-stimulated glucose transport is normalized in vitro in the presence of euglycemia, but not in the presence of hyperglycemia. Thus, the circulating level of glucose may independently regulate insulin stimulated glucose transport in skeletal muscle from NIDDM patients via a down regulation of the insulin signaling cascade.
Indexed as
Identifiers
9609124W1539328421What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.