ReviewMolecular and cellular biochemistry1998
Regulation of the Na+/K+-ATPase by insulin: why and how?
Review in Molecular and cellular biochemistry, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 146 citations in OpenAlex.
- Caffeine ingestion stimulates plasma carnitine clearance in humans.Physiological reports · 2023Trial
- Common metabolic features of hypertension and type 2 diabetes.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- Review
- Some Kinetic Features of Na,K-ATPase and Sensitivity to Noradrenaline.Cell biochemistry and biophysics · 2022Article
- Insulin stimulates β-alanine uptake in skeletal muscle cells in vitro.Amino acids · 2021Article
- Discovery and implications of polygenicity of common diseases.Science (New York, N.Y.) · 2021Review
- Skeletal muscle proteins important for work capacity are altered with type 2 diabetes - Effect of 10-20-30 training.Physiological reports · 2021Article
- Comparison of Serum Levels of Fructosamine and Erythrocyte Sodium Potassium ATPase (NaReports of biochemistry & molecular biology · 2019Article
- Hypertension with diabetes mellitus: physiology and pathology.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Review
- Selective lysis of breast carcinomas by simultaneous stimulation of sodium channels and blockade of sodium pumps.Oncotarget · 2018Article
- The pump, the exchanger, and the holy spirit: origins and 40-year evolution of ideas about the ouabain-NaAmerican journal of physiology. Cell physiology · 2018Review
- Src Family Kinase Links Insulin Signaling to Short Term Regulation of Na,K-ATPase in Nonpigmented Ciliary Epithelium.Journal of cellular physiology · 2017Article
- Chronic insulin treatment phosphorylates the renal Na-K-ATPase α1-subunit at serine 16/23 and reduces its activity involving PI3-kinase-dependent PKC activation.American journal of physiology. Renal physiology · 2016Article
- Featured Article: Inhibition of diabetic cataract by glucose tolerance factor extracted from yeast.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Akt Substrate of 160 kD Regulates Na+,K+-ATPase Trafficking in Response to Energy Depletion and Renal Ischemia.Journal of the American Society of Nephrology : JASN · 2015Article
- Effects of glutamate on growth, antioxidant capacity, and antioxidant-related signaling molecule expression in primary cultures of fish enterocytes.Fish physiology and biochemistry · 2015Article
- Insulin induces phosphorylation of serine residues of translationally controlled tumor protein in 293T cells.International journal of molecular sciences · 2015Article
- The metabolism hypothesis of Alzheimer's disease: from the concept of central insulin resistance and associated consequences to insulin therapy.Journal of neural transmission (Vienna, Austria : 1996) · 2015Review
- Transcriptional regulators of Na,K-ATPase subunits.Frontiers in cell and developmental biology · 2015Review
- Up-regulation of Rhoa/Rho kinase pathway by translationally controlled tumor protein in vascular smooth muscle cells.International journal of molecular sciences · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sodium-potassium ATPase (Na+/K+-ATPase or Na+/K+-pump) is an enzyme present at the surface of all eukaryotic cells, which actively extrudes Na+ from cells in exchange for K+ at a ratio of 3:2, respectively. Its activity also provides the driving force for secondary active transport of solutes such as amino acids, phosphate, vitamins and, in epithelial cells, glucose. The enzyme consists of two subunits (alpha and beta) each expressed in several isoforms. Many hormones regulate Na+/K+-ATPase activity and in this review we will focus on the effects of insulin. The possible mechanisms whereby insulin controls Na+/K+-ATPase activity are discussed. These are tissue- and isoform-specific, and include reversible covalent modification of catalytic subunits, activation by a rise in intracellular Na+ concentration, altered Na+ sensitivity and changes in subunit gene or protein expression. Given the recent escalation in knowledge of insulin-stimulated signal transduction systems, it is pertinent to ask which intracellular signalling pathways are utilized by insulin in controlling Na+/K+-ATPase activity. Evidence for and against a role for the phosphatidylinositol-3-kinase and mitogen activated protein kinase arms of the insulin-stimulated intracellular signalling networks is suggested. Finally, the clinical relevance of Na+/K+-ATPase control by insulin in diabetes and related disorders is addressed.
Indexed as
Identifiers
9609121W1514745038What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.