ReviewMolecular and cellular biochemistry1998
Insulin regulation of the Ras activation/inactivation cycle.
Review in Molecular and cellular biochemistry, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 44 citations in OpenAlex.
- Metformin and the PI3K/AKT signaling pathway: implications for cancer, cardiovascular, and central nervous system diseases.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Inferring Intracellular Signal Transduction Circuitry from Molecular Perturbation Experiments.Bulletin of mathematical biology · 2018Article
- Modulation of insulin-like growth factor-1 receptor and its signaling network for the treatment of cancer: current status and future perspectives.Oncology reviews · 2013Review
- Insulin receptor-independent upregulation of cellular glucose uptake.International journal of obesity (2005) · 2013Article
- Insulin resistance and cancer risk: an overview of the pathogenetic mechanisms.Experimental diabetes research · 2012Review
- Article
- The insulin receptor: a new target for cancer therapy.Frontiers in endocrinology · 2011Article
- PPAR-γ agonists and their effects on IGF-I receptor signaling: Implications for cancer.PPAR research · 2009Article
- IGF and insulin receptor signaling in breast cancer.Journal of mammary gland biology and neoplasia · 2008Article
- Chronic exposure to ketone bodies impairs glucose uptake in adult cardiomyocytes in response to insulin but not vanadate: the role of PI3-K.Molecular and cellular biochemistry · 2007Article
- Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.The Journal of cell biology · 2002Article
- The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain.The EMBO journal · 2000Article
- Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways.Molecular and cellular biology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to mediating a number of metabolic functions, insulin also uses mitogenic pathways to maintain cellular homeostasis. Many of these mitogenic responses are mediated by signals through the small molecular weight guanine nucleotide binding protein, Ras. In the last decade, great progress has been made in understanding the molecular mechanisms which regulate the insulin mediated conversion of Ras from its inactive, GDP-bound state, to the activated GTP-bound form. More recently, it has been appreciated that insulin also regulates the inactivation of this pathway, namely by uncoupling the protein complexes whose formation is required for Ras activation. This review addresses molecular mechanism which both positively and negatively regulate this mitogenic signalling pathway.
Indexed as
Identifiers
9609111W1543185417What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.