ReviewMolecular and cellular biochemistry1998
Role of binding proteins to IRS-1 in insulin signalling.
Review in Molecular and cellular biochemistry, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Bidirectional Relationship Between Anaesthetic Drugs and Metabolic Syndrome: Clinical Effects and Mechanisms.Journal of cellular and molecular medicine · 2025Review
- The Diurnal Rhythm of Insulin Receptor Substrate-1 (IRS-1) and Kir4.1 in Diabetes: Implications for a Clock Gene Bmal1.Investigative ophthalmology & visual science · 2019Article
- Oleate Prevents Palmitate-Induced Atrophy via Modulation of Mitochondrial ROS Production in Skeletal Myotubes.Oxidative medicine and cellular longevity · 2017Article
- Effects of exendin-4 and selenium on the expression of GLP-1R, IRS-1, and preproinsulin in the pancreas of diabetic rats.Journal of physiology and biochemistry · 2016Article
- PfIRR Interacts with HrIGF-I and Activates the MAP-kinase and PI3-kinase Signaling Pathways to Regulate Glycogen Metabolism in Pinctada fucata.Scientific reports · 2016Article
- Cytoprotective effect of hispidin against palmitate-induced lipotoxicity in C2C12 myotubes.Molecules (Basel, Switzerland) · 2015Article
- Messenger RNA sequencing and pathway analysis provide novel insights into the biological basis of chickens' feed efficiency.BMC genomics · 2015Article
- The impact of host diet on Wolbachia titer in Drosophila.PLoS pathogens · 2015Article
- Induction of insulin resistance by the adipokines resistin, leptin, plasminogen activator inhibitor-1 and retinol binding protein 4 in human megakaryocytes.Haematologica · 2012Article
- The hepatitis C virus modulates insulin signaling pathway in vitro promoting insulin resistance.PloS one · 2012Article
- Klotho and the aging process.The Korean journal of internal medicine · 2011Review
- Frontier of epilepsy research - mTOR signaling pathway.Experimental & molecular medicine · 2011Review
- Oxidative stress, insulin signaling, and diabetes.Free radical biology & medicine · 2011Review
- Insulin-like growth factor-I-stimulated insulin receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells.The Journal of biological chemistry · 2010Article
- Potential physiological effects of pharmaceutical compounds in Atlantic salmon (Salmo salar) implied by transcriptomic analysis.Environmental science and pollution research international · 2010Article
- Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination.Molecular and cellular endocrinology · 2009Review
- Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.Molecular systems biology · 2009Article
- Insulin inhibits platelet-derived growth factor-induced cell proliferation.Molecular biology of the cell · 2005Article
- PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity.The Journal of clinical investigation · 2003Article
- Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver.The Journal of clinical investigation · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin elicits its divergent metabolic and mitogenic effects by binding to its specific receptor, which belongs to the family of receptor tyrosine kinases. The activated insulin receptor phosphorylates the intracellular substrate IRS-1, which then binds various signalling molecules that contain SRC homology 2 domains, thereby propagating the insulin signal. Among these IRS-1-binding proteins, the Grb2-Sos complex and the protein tyrosine phosphatase SHP-2 transmit mitogenic signals through the activation of Ras, and phosphoinositide 3-kinase is implicated in the major metabolic actions of insulin. Although substantial evidence indicates the importance of IRS-1 in insulin signal transduction, the generation of IRS-1-deficient mice has revealed the existence of redundant signalling pathways.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.