ArticleProceedings. Biological sciences1998
The role of parasite-induced immunodepression, rank and social environment in the modulation of behaviour and hormone concentration in male laboratory mice (Mus musculus).
Article in Proceedings. Biological sciences, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Social status, immune response and parasitism in males: a meta-analysis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Pooled it
- Sex-the most underappreciated variable in research: insights from helminth-infected hosts.Veterinary research · 2022Review
- Galectins - Important players of the immune response to CNS parasitic infection.Brain, behavior, & immunity - health · 2021Review
- Effects ofPathogens (Basel, Switzerland) · 2020Article
- Endocrine and immune responses of larval amphibians to trematode exposure.Parasitology research · 2019Article
- Corticosterone: a costly mediator of signal honesty in sand lizards.Ecology and evolution · 2016Article
- Towards an integrative model of sociality in caviomorph rodents.Journal of mammalogy · 2011Article
- Social status does not predict responses to Seoul virus infection or reproductive success among male Norway rats.Brain, behavior, and immunity · 2006Article
- Maternal effects on the development of social rank and immunity trade-offs in male laboratory mice (Mus musculus).Proceedings. Biological sciences · 1998Article
- Parasitized female mice display reduced aversive responses to the odours of infected males.Proceedings. Biological sciences · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral immune responsiveness in male laboratory mice was reduced by infection with the trichostrongyloid nematode Heligmosomoides polygyrus. Responsiveness was also lower among high-ranking (aggressive) males regardless of infection status. Reduced responsiveness in both infected animals and high rankers was associated with elevated serum corticosterone concentration (a potential immunodepressant) and was compounded among high-ranking males by subsequent high aggressiveness. As in previous experiments, only low rankers modulated testosterone secretion in relation to current immunocompetence and corticosterone concentration. The lack of any downregulation of aggression in response to parasite-induced immunodepression contrasted with previous results using antithymocyte serum and may be due to the more localized nature of immunodepression during H. polygyrus infection. However, the additional increase in corticosterone concentration resulting from exposure to female odour and destabilized aggressive social relationships did result in downregulation of aggression among high rankers and of testosterone among mice generally, suggesting that modulation rules of thumb are at least partly dependent on the proximate cues associated with immunodepression.
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