ArticleProceedings. Biological sciences1998
Identification of Ca(2+)-activated K+ channel splice variants and their distribution in the turtle cochlea.
Article in Proceedings. Biological sciences, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- The mechanism of CaThe Journal of biological chemistry · 2025Article
- Alternative splicing in shaping the molecular landscape of the cochlea.Frontiers in cell and developmental biology · 2023Review
- Of mice and chickens: Revisiting the RC time constant problem.Hearing research · 2022Review
- CDK5 interacts with Slo and affects its surface expression and kinetics through direct phosphorylation.American journal of physiology. Cell physiology · 2012Article
- Splicing of the rSlo gene affects the molecular composition and drug response of Ca2+-activated K+ channels in skeletal muscle.PloS one · 2012Article
- β4-subunit increases Slo responsiveness to physiological Ca2+ concentrations and together with β1 reduces surface expression of Slo in hair cells.American journal of physiology. Cell physiology · 2011Article
- Highly specific alternative splicing of transcripts encoding BK channels in the chicken's cochlea is a minor determinant of the tonotopic gradient.Molecular and cellular biology · 2010Article
- Expression of BK-type calcium-activated potassium channel splice variants during chick cochlear development.The Journal of comparative neurology · 2010Article
- Control of alternative pre-mRNA splicing by Ca(++) signals.Biochimica et biophysica acta · 2008Review
- Ion channel gene expression in the inner ear.Journal of the Association for Research in Otolaryngology : JARO · 2007Article
- Alternative splicing of the Ca(v)1.3 channel IQ domain, a molecular switch for Ca2+-dependent inactivation within auditory hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Ca(2+) and K(+) (BK) channels in chick hair cells are clustered and colocalized with apical-basal and tonotopic gradients.The Journal of physiology · 2004Article
- Effects of intracellular stores and extracellular Ca(2+) on Ca(2+)-activated K(+) currents in mature mouse inner hair cells.The Journal of physiology · 2004Article
- The distribution of calcium buffering proteins in the turtle cochlea.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Consequences of the stoichiometry of Slo1 alpha and auxiliary beta subunits on functional properties of large-conductance Ca2+-activated K+ channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Rapidly inactivating and non-inactivating calcium-activated potassium currents in frog saccular hair cells.The Journal of physiology · 2001Article
- Contribution of potential EF hand motifs to the calcium-dependent gating of a mouse brain large conductance, calcium-sensitive K(+) channel.The Journal of physiology · 2001Article
- Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- beta subunits modulate alternatively spliced, large conductance, calcium-activated potassium channels of avian hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- The role of Ca2+-activated K+ channel spliced variants in the tonotopic organization of the turtle cochlea.The Journal of physiology · 1999Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Turtle auditory-hair cells are frequency-tuned by the activity of calcium-activated potassium (KCa) channels, a cell's characteristic frequency being determined by the KCa channel density and kinetics which both vary systematically along the cochlea. As a first step towards identifying the source of KCa channel variation, we have isolated, by reverse-transcription polymerase chain reaction on dissociated hair cells, the main cDNAs homologous to the slo gene which encodes the channel's alpha-subunit. A total of six alternatively spliced variants were identified, the smallest of which is 94% identical to a mouse Slo sequence. Variation occurs by insertion of exons at only two splice sites, two of these exons encoding novel 31- and 61-amino acid sequences. As we were unable to detect splicing at other potential sites, we infer that the six variants correspond to naturally occurring combinations. The spatial distribution of the variants, defined by isolating hair cells from different regions of the cochlea, indicated that some isoforms were non-uniformly distributed. Those containing large inserts in the first splice site were notably absent from the highest-frequency region. We suggest that alternative splicing of the slo gene may contribute to variation in KCa channel properties.
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