ArticleThe Journal of experimental medicine1998
Quantitative analysis of the T cell repertoire selected by a single peptide-major histocompatibility complex.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- ImSpectR - R package to quantify immune repertoire diversity in spectratype and repertoire sequencing data.Bioinformatics (Oxford, England) · 2019Article
- Article
- The past, present, and future of immune repertoire biology - the rise of next-generation repertoire analysis.Frontiers in immunology · 2013Review
- The etiology of paraneoplastic autoimmunity.Clinical reviews in allergy & immunology · 2012Review
- Evolutionarily conserved amino acids that control TCR-MHC interaction.Annual review of immunology · 2008Review
- Prss16 is not required for T-cell development.Molecular and cellular biology · 2005Article
- Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Predominant role of T cell receptor (TCR)-alpha chain in forming preimmune TCR repertoire revealed by clonal TCR reconstitution system.The Journal of experimental medicine · 2002Article
- Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Identical T cell clones are located within the mouse gut epithelium and lamina propia and circulate in the thoracic duct lymph.The Journal of experimental medicine · 2000Article
- The effect of graft-versus-host disease on T cell production and homeostasis.The Journal of experimental medicine · 1999Article
- Highly restricted T cell repertoire shaped by a single major histocompatibility complex-peptide ligand in the presence of a single rearranged T cell receptor beta chain.The Journal of experimental medicine · 1998Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The positive selection of CD4+ T cells requires the expression of major histocompatibility complex (MHC) class II molecules in the thymus, but the role of self-peptides complexed to class II molecules is still a matter of debate. Recently, it was observed that transgenic mice expressing a single peptide-MHC class II complex positively select significant numbers of diverse CD4+ T cells in the thymus. However, the number of selected T cell specificities has not been evaluated so far. Here, we have sequenced 700 junctional complementarity determining regions 3 (CDR3) from T cell receptors (TCRs) carrying Vbeta11-Jbeta1.1 or Vbeta12-Jbeta1.1 rearrangements. We found that a single peptide-MHC class II complex positively selects at least 10(5) different Vbeta rearrangements. Our data yield a first evaluation of the size of the T cell repertoire. In addition, they provide evidence that the single Ealpha52-68-I-Ab complex skews the amino acid frequency in the TCR CDR3 loop of positively selected T cells. A detailed analysis of CDR3 sequences indicates that a fraction of the beta chain repertoire bears the imprint of the selecting self-peptide.
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