ArticleThe Journal of experimental medicine1998
An alternate pathway for T cell development supported by the bone marrow microenvironment: recapitulation of thymic maturation.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Beyond the skin barrier: commensalbioRxiv : the preprint server for biology · 2026Article
- Regulation of normal and leukemic stem cells through cytokine signaling and the microenvironment.International journal of hematology · 2017Review
- Alloimmune response results in expansion of autoreactive donor CD4+ T cells in transplants that can mediate chronic graft-versus-host disease.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Immunotherapy of cancer for the elderly patient: does allogeneic bone marrow transplantation after nonmyeloablative conditioning provide a new option?Cancer immunology, immunotherapy : CII · 2004Review
- T lymphoid differentiation in human bone marrow.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Amplification of T cells from human cord blood in serum-deprived culture stimulated with stem cell factor, interleukin-7 and interleukin-2.Bone marrow transplantation · 2003Article
- Clonable progenitors committed to the T lymphocyte lineage in the mouse bone marrow; use of an extrathymic pathway.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Expression of IL-5 alters bone metabolism and induces ossification of the spleen in transgenic mice.The Journal of clinical investigation · 2001Article
- Identification of an early T cell progenitor for a pathway of T cell maturation in the bone marrow.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Direct evidence for thymic function in adult humans.The Journal of experimental medicine · 1999Article
- Article
- Identification of lymphomyeloid primitive progenitor cells in fresh human cord blood and in the marrow of nonobese diabetic-severe combined immunodeficient (NOD-SCID) mice transplanted with human CD34(+) cord blood cells.The Journal of experimental medicine · 1999Article
- The effect of graft-versus-host disease on T cell production and homeostasis.The Journal of experimental medicine · 1999Article
- Bone marrow NK1.1(-) and NK1.1(+) T cells reciprocally regulate acute graft versus host disease.The Journal of experimental medicine · 1999Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In the principal pathway of alpha/beta T cell maturation, T cell precursors from the bone marrow migrate to the thymus and proceed through several well-characterized developmental stages into mature CD4+ and CD8+ T cells. This study demonstrates an alternative pathway in which the bone marrow microenvironment also supports the differentiation of T cell precursors into CD4+ and CD8+ T cells. The marrow pathway recapitulates developmental stages of thymic maturation including a CD4+CD8+ intermediary cell and positive and negative selection, and is strongly inhibited by the presence of mature T cells. The contribution of the marrow pathway in vivo requires further study in mice with normal and deficient thymic or immune function.
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Registered trials
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