ArticleThe Journal of experimental medicine1998
Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- Repertoire Sequencing of B Cells Elucidates the Role of UNG and Mismatch Repair Proteins in Somatic Hypermutation in Humans.Frontiers in immunology · 2019Pooled it
- Gene co-expression network analysis reveals relationship between leukocyte fraction and genomic instability in dedifferentiated liposarcoma.Molecular biology research communications · 2025Article
- Tandem Substitutions in Somatic Hypermutation.Frontiers in immunology · 2021Article
- Immunomodulatory Roles of PARP-1 and PARP-2: Impact on PARP-Centered Cancer Therapies.Cancers · 2020Review
- Restriction of AID activity and somatic hypermutation by PARP-1.Nucleic acids research · 2019Article
- Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.Nucleic acids research · 2017Article
- The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation.Cell reports · 2016Article
- Parp3 negatively regulates immunoglobulin class switch recombination.PLoS genetics · 2015Article
- Simultaneous in vitro characterisation of DNA deaminase function and associated DNA repair pathways.PloS one · 2013Article
- Article
- The BRCT domain of PARP-1 is required for immunoglobulin gene conversion.PLoS biology · 2010Article
- MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites.PloS one · 2010Article
- AID and somatic hypermutation.Advances in immunology · 2010Review
- Poly(ADP-ribose) polymerase-1 (Parp-1)-deficient mice demonstrate abnormal antibody responses.Immunology · 2009Article
- Hijacked DNA repair proteins and unchained DNA polymerases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigenK164R mutant mice.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Article
- Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.DNA repair · 2008Article
- Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination.DNA repair · 2007Article
- A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification.The Journal of experimental medicine · 2007Article
- Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias.Molecular immunology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the possible involvement of DNA repair in the process of somatic hypermutation of rearranged immunoglobulin variable (V) region genes, we have analyzed the occurrence, frequency, distribution, and pattern of mutations in rearranged Vlambda1 light chain genes from naive and memory B cells in DNA repair-deficient mutant mouse strains. Hypermutation was found unaffected in mice carrying mutations in either of the following DNA repair genes: xeroderma pigmentosum complementation group (XP)A and XPD, Cockayne syndrome complementation group B (CSB), mutS homologue 2 (MSH2), radiation sensitivity 54 (RAD54), poly (ADP-ribose) polymerase (PARP), and 3-alkyladenine DNA-glycosylase (AAG). These results indicate that both subpathways of nucleotide excision repair, global genome repair, and transcription-coupled repair are not required for somatic hypermutation. This appears also to be true for mismatch repair, RAD54-dependent double-strand-break repair, and AAG-mediated base excision repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.