ArticleThe Journal of infectious diseases1998
Tumor necrosis factor-alpha, interleukin-6, and interleukin-8 secretion and the acute-phase response in patients with bacterial and tuberculous osteomyelitis.
Article in The Journal of infectious diseases, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- Association of serum albumin concentration with mortality, morbidity, CD4 T-cell reconstitution among tanzanians initiating antiretroviral therapy.The Journal of infectious diseases · 2013Trial
- Osteomyelitis: Epidemiology, Classification, Pathophysiology, Clinical Features, Diagnosis, and Management.MedComm · 2026Review
- Dual-Scale StaphAIR: Predictive Modeling for the Diagnosis ofAnalytical chemistry · 2026Article
- Establishment of a mandible defect model in rabbits infected with multiple bacteria and bioinformatics analysis.Frontiers in bioengineering and biotechnology · 2024Article
- Osteomyelitis, Oxidative Stress and Related Biomarkers.Antioxidants (Basel, Switzerland) · 2022Review
- The osteoblast secretome inFrontiers in immunology · 2022Review
- Histological Identification of Sequestered Parasitized Red Cells.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Different Modulatory Effects of Four Methicillin-ResistantBiomolecules · 2021Article
- Osteoarthritic process modifies expression response to NiTi alloy presence.Journal of materials science. Materials in medicine · 2018Article
- Staphylococcus aureus-dependent septic arthritis in murine knee joints: local immune response and beneficial effects of vaccination.Scientific reports · 2016Article
- Contribution of Reduced Interleukin-10 Levels to the Pathogenesis of Osteomyelitis in Children with Sickle Cell Disease.Clinical and vaccine immunology : CVI · 2015Article
- Free radicals and antioxidant status in chronic osteomyelitis patients: a case control study.Journal of clinical and diagnostic research : JCDR · 2015Article
- Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients.International journal of medical sciences · 2015Article
- Comparison of platelet count in tuberculosis spine to other spine pathology.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2013Article
- Staphylococcus aureus protein A plays a critical role in mediating bone destruction and bone loss in osteomyelitis.PloS one · 2012Article
- Interaction of staphylococci with bone.International journal of medical microbiology : IJMM · 2010Review
- Current trends in the management of ocular symptoms in Adamantiades-Behçet's disease.Clinical ophthalmology (Auckland, N.Z.) · 2009Article
- Influence of interleukin 1alpha (IL-1alpha), IL-4, and IL-6 polymorphisms on genetic susceptibility to chronic osteomyelitis.Clinical and vaccine immunology : CVI · 2008Article
- Potential role of interleukin 6 in reactive thrombocytosis and acute phase response in pulmonary tuberculosis.Postgraduate medical journal · 2005Article
- In vivo interleukin-6 protects neutrophils from apoptosis in osteomyelitis.Infection and immunity · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Osteomyelitis, or bone infection, is a major worldwide cause of morbidity. Treatment is frequently unsatisfactory, yet little is known about pathogenesis of infection. Plasma tumor necrosis factor (TNF), interleukin (IL)-6, and IL-8 concentrations were measured before and after lipopolysaccharide stimulation of whole blood from patients with bacterial and tuberculous osteomyelitis and from controls. Patients with bacterial and tuberculous osteomyelitis mounted an acute-phase response and were anemic and febrile. However, plasma IL-6 concentrations were significantly elevated in only tuberculous osteomyelitis patients (vs. controls, P < .05). IL-6 concentrations correlated with erythrocyte sedimentation rate, C-reactive protein level, and plasma albumin concentration, all acute-phase markers. There were no other correlations between cytokine concentrations and clinical data. Following ex vivo stimulation, TNF, IL-6, and IL-8 were secreted equally by patients and controls. In summary, tuberculous osteomyelitis is characterized by elevated systemic IL-6 concentrations associated with an acute-phase response. For further insight into immunopathology of osteomyelitis, studies on infected bone are required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.