ReviewDrugs & aging1998
Cytokines in rheumatoid arthritis. Potential targets for pharmacological intervention.
Review in Drugs & aging, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 70 citations in OpenAlex.
- Decrease in circulating endothelial cell adhesion molecule and thrombomodulin levels during oral iloprost treatment in rheumatoid arthritis patients: preliminary results.Rheumatology international · 2006Trial
- Effects of 1-year tofacitinib therapy on angiogenic biomarkers in rheumatoid arthritis.Rheumatology (Oxford, England) · 2023Article
- Hidden attributes of zymosan in the pathogenesis of inflammatory diseases: A tale of the fungal agent.Iranian journal of basic medical sciences · 2023Review
- Effects of tofacitinib therapy on arginine and methionine metabolites in association with vascular pathophysiology in rheumatoid arthritis: A metabolomic approach.Frontiers in medicine · 2022Article
- Boi-ogi-to (TJ-20), a Kampo Formula, Suppresses the Inflammatory Bone Destruction and the Expression of Cytokines in the Synovia of Ankle Joints of Adjuvant Arthritic Rats.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Colony-Specific Differences in Endocrine and Immune Responses to an Inflammatory Challenge in Female Sprague Dawley Rats.Endocrinology · 2015Article
- Article
- Evaluation of Protective Efficacy of Avicennia marina (Forssk.) Vierh Leaves against Complete Freund᾽s Adjuvant-induced Arthritis in Wistar.Iranian journal of pharmaceutical research : IJPR · 2014Article
- Protective efficacy of N-(2-hydroxyphenyl) acetamide against adjuvant-induced arthritis in rats.BioMed research international · 2013Article
- Antihyperglycemic, hypolipidemic and antioxidant activities of ethanolic extract of Commiphora mukul gum resin in fructose-fed male Wistar rats.Journal of physiology and biochemistry · 2012Article
- The anti-arthritic and anti-oxidative effect of NBD (6-nitro-1,3-benzodioxane) in adjuvant-induced arthritis (AIA) in rats.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Chemokines and chemokine receptors in arthritis.Frontiers in bioscience (Scholar edition) · 2010Review
- Monocytes/macrophages express chemokine receptor CCR9 in rheumatoid arthritis and CCL25 stimulates their differentiation.Arthritis research & therapy · 2010Article
- Angiogenesis in rheumatoid arthritis.Autoimmunity · 2009Review
- Angiogenesis and its targeting in rheumatoid arthritis.Vascular pharmacology · 2009Review
- Chemokines and angiogenesis in rheumatoid arthritis.Frontiers in bioscience (Elite edition) · 2009Review
- Targeting Angiogenesis in Rheumatoid Arthritis.Current rheumatology reviews · 2008Article
- The comparative study of Sprague-Dawley and Lewis rats in adjuvant-induced arthritis.Naunyn-Schmiedeberg's archives of pharmacology · 2006Article
- CXCL16-mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent upon the MAPK pathway.Arthritis and rheumatism · 2006Article
- The inhibitory effect of disease-modifying anti-rheumatic drugs and steroids on gliostatin/platelet-derived endothelial cell growth factor production in human fibroblast-like synoviocytes.Rheumatology international · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The ingress of inflammatory leucocytes into the synovium is a crucial step in the pathogenesis of rheumatoid arthritis (RA). Cytokines are mediators involved in the inflammatory events, adhesive mechanisms, angiogenesis and osteopenia associated with RA. Pro- and anti-inflammatory cytokines, growth factors and chemokines all have an important role in these processes. Because the efficacy of currently used antirheumatic therapy is often limited, there is a need for more specific intervention strategies. Anticytokine therapy may include the use of monoclonal antibodies, antagonistic cytokines, soluble cytokine receptors, cytokine receptor antagonists, somatic gene transfer or other approaches. Hopefully, the study of cytokines and their interactions will lead to the development of new immunomodulatory strategies that will benefit patients with RA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.