ArticleThe EMBO journal1998
Nascent transcription from the nmt1 and nmt2 genes of Schizosaccharomyces pombe overlaps neighbouring genes.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Genome-wide mapping of polyadenylation sites in fission yeast reveals widespread alternative polyadenylation.RNA biology · 2013Article
- RNAi genes pave their own way.Genes & development · 2011Article
- Autoregulation of convergent RNAi genes in fission yeast.Genes & development · 2011Article
- A meiotic gene regulatory cascade driven by alternative fates for newly synthesized transcripts.Molecular biology of the cell · 2011Article
- A complex gene regulatory mechanism that operates at the nexus of multiple RNA processing decisions.Nature structural & molecular biology · 2009Article
- mRNA processing in Antonospora locustae spores.Molecular genetics and genomics : MGG · 2008Article
- A high frequency of overlapping gene expression in compacted eukaryotic genomes.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- DNA replication origins in the Schizosaccharomyces pombe genome.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Premature termination of RNA polymerase II mediated transcription of a seed protein gene in Schizosaccharomyces pombe.Nucleic acids research · 2002Article
- Transcriptional collision between convergent genes in budding yeast.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- The Arabidopsis PILZ group genes encode tubulin-folding cofactor orthologs required for cell division but not cell growth.Genes & development · 2002Article
- Glucose-inducible expression of rrg1+ in Schizosaccharomyces pombe: post-transcriptional regulation of mRNA stability mediated by the downstream region of the poly(A) site.Nucleic acids research · 2002Article
- Mechanism of poly(A) signal transduction to RNA polymerase II in vitro.Molecular and cellular biology · 2001Article
- The stress-activated MAP kinase Sty1/Spc1 and a 3'-regulatory element mediate UV-induced expression of the uvi15(+) gene at the post-transcriptional level.Nucleic acids research · 2000Article
- Definition of transcriptional pause elements in fission yeast.Molecular and cellular biology · 1999Article
- Poly(A) signals control both transcriptional termination and initiation between the tandem GAL10 and GAL7 genes of Saccharomyces cerevisiae.The EMBO journal · 1998Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have determined the extent of the primary transcription unit for the two highly expressed genes nmt1 and nmt2 of Schizosaccharomyces pombe. Transcription run-on analysis in permeabilized yeast cells was employed to map polymerase density across the 3'-flanking region of these two genes. Surprisingly, polymerases were detected 4.3 kb beyond the nmt1 polyadenylation [poly(A)] site and 2.4 kb beyond the nmt2 poly(A) site, which in each case have transcribed through an entire convergent downstream transcription unit. However, the steady-state levels of both downstream genes were unaffected by the high level of nmt1 or nmt2 nascent transcription. Analysis of nmt1 and nmt2 RNA 3' end formation signals indicates that efficient termination of transcription requires not only a poly(A) signal but also additional pause elements. The absence of such pause elements close to the poly(A) sites of these genes may account for their extended nascent transcripts.
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