ArticleJournal of assisted reproduction and genetics1998
Successful use of a laser for human embryo biopsy in preimplantation genetic diagnosis: report of two cases.
Article in Journal of assisted reproduction and genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07691073 (The Impact of Ovarian Stimulation With hMG on Embryo Quality in Advanced Age Women. A Randomized Controlled Trial), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Ovarian Stimulation With hMG on Embryo Quality in Advanced Age Women. A Randomized Controlled Trial
Who cites it
13 citing papers in PubMed.
- Should embryo rebiopsy be considered a regular strategy to increase the number of embryos available for transfer?Journal of assisted reproduction and genetics · 2023Article
- The effect of trophectoderm biopsy technique and sample handling on artefactual mosaicism.Journal of assisted reproduction and genetics · 2022Observational
- From Zygote to Blastocyst: Application of Ultrashort Lasers in the Field of Assisted Reproduction and Developmental Biology.Diagnostics (Basel, Switzerland) · 2021Review
- Preimplantation Genetic Screening and The Success Rate ofCell journal · 2021Article
- Is sex ratio at birth an appropriate measure of prenatal sex selection? Findings of a theoretical model and its application to India.BMJ global health · 2018Article
- Arrested human embryos are more likely to have abnormal chromosomes than developing embryos from women of advanced maternal age.Journal of ovarian research · 2014Article
- Preimplantation genetic diagnosis guided by single-cell genomics.Genome medicine · 2013Review
- Vitrified blastocysts from Preimplantation Genetic Diagnosis (PGD) as a source for human Embryonic Stem Cell (hESC) derivation.Journal of assisted reproduction and genetics · 2012Article
- Outcomes of preimplantation genetic diagnosis using either zona drilling with acidified Tyrode's solution or partial zona dissection.Clinical and experimental reproductive medicine · 2012Article
- Are zona pellucida laser drilling and polar body biopsy safe for in vitro matured oocytes?Journal of assisted reproduction and genetics · 2010Article
- Birth after transfer of frozen-thawed vitrified biopsied blastocysts.Journal of assisted reproduction and genetics · 2007Article
- Noncontact, laser-mediated extraction of polar bodies for prefertilization genetic diagnosis.Journal of assisted reproduction and genetics · 2002Article
- Preimplantation genetics.Journal of assisted reproduction and genetics · 1998Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe use of Tyrode's acid to drill the zona pellucida for embryo biopsy is the most widely used methodology in preimplantation genetic diagnosis. Instead of this, we propose the use of a 1.48-micron diode noncontact laser, which is quicker, simpler, and safer.
methodsThe laser beam was tangentially guided to the zona pellucida of the embryo. Depending on zona pellucida measurement, two to four consecutive shots of 8-22 msec were necessary to drill the zona pellucida of the 13 embryos biopsied for two patients (hemophilia carriers).
resultsFemale embryos were replaced into the uterus of the patients (1.5 embryos/replacement). One single pregnancy was established (33.3% implantation rate). Coculture of untransferable embryos showed a blastocyst rate of 66.7% (4/6) for male embryos and 25% (1/4) for abnormal ones.
conclusionsThese results demonstrate the safety and usefulness of laser methodology in preimplantation genetic diagnosis.
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