ArticleJournal of assisted reproduction and genetics1998
Incidence of chromosomal abnormalities from a morphologically normal cohort of embryos in poor-prognosis patients.
Article in Journal of assisted reproduction and genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sequential embryo transfer efficacy in enhancing pregnancy outcomes: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2025Pooled it
- Cleavage-stage versus blastocyst-stage embryo transfer in assisted reproductive technology.The Cochrane database of systematic reviews · 2022Pooled it
- Effect of Day 3 cell number on the live birth rate of vitrified-warmed Day 5 single blastocyst transfer in young women.BMC pregnancy and childbirth · 2024Article
- Rate of Post-Fertilization Mitotic Activity Predicts Embryonic Competence via Next Generation Sequencing: An Analysis of 39,301 Cleavage Stage Embryos.JBRA assisted reproduction · 2021Article
- The Development of Nomograms to Predict Blastulation Rate Following Cycles ofFrontiers in endocrinology · 2021Article
- Prospects of Germline Nuclear Transfer in Women With Diminished Ovarian Reserve.Frontiers in endocrinology · 2021Review
- Article
- Embryos derived from donor or patient oocytes are not different for in vitro fertilization outcomes when PGT allows euploid embryo selection: a retrospective study.Clinical and translational medicine · 2020Article
- The Feasibility of All-Blastocyst-Culture and Single Blastocyst Transfer Strategy in Elderly Women: A Retrospective Analysis.BioMed research international · 2020Article
- Observational
- Article
- High Aneuploidy Rates Observed in Embryos Derived from Donated Oocytes are Related to Male Aging and High Percentages of Sperm DNA Fragmentation.Clinical medicine insights. Reproductive health · 2015Article
- Expression profiles of cohesins, shugoshins and spindle assembly checkpoint genes in rhesus macaque oocytes predict their susceptibility for aneuploidy during embryonic development.Cell cycle (Georgetown, Tex.) · 2012Article
- Down-regulation of HLA-G Attenuates Cleavage Rate in Human Triploid Embryos.Journal of reproduction & infertility · 2011Article
- Are poor responders patients at higher risk for producing aneuploid embryos in vitro?Journal of assisted reproduction and genetics · 2011Article
- The utility of embryo banking in order to increase the number of embryos available for preimplantation genetic screening in advanced maternal age patients.Journal of assisted reproduction and genetics · 2010Article
- Incidence of chromosomal mosaicism in morphologically normal nonhuman primate preimplantation embryos.Fertility and sterility · 2010Article
- Association of BRCA1 mutations with occult primary ovarian insufficiency: a possible explanation for the link between infertility and breast/ovarian cancer risks.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2010Article
- Chromosomal instability in rhesus macaque preimplantation embryos.Fertility and sterility · 2009Article
- Protein nanotechnology - A powerful futuristic diagnostic technique.Indian journal of clinical biochemistry : IJCB · 2005Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePreimplantation genetic diagnosis of aneuploidy was performed on the embryos yielded by 70 poor-prognosis patients, with the aim of transferring those with a normal chromosomal complement, thus possibly increasing the chances of pregnancy.
methodsMulticolor fluorescence in situ hybridization (FISH) was applied for the simultaneous detection of chromosomes X, Y, 13, 16, 18, and 21. Inclusion criteria were (1) a maternal age of 36 years or older (n = 33), (2) three or more previous in vitro fertilization cycles (n = 20), and (3) an altered karyotype (n = 17).
resultsA total of 412 embryos underwent FISH, resulting in 234 (57%) that were chromosomally abnormal. Euploid embryos were available for transfer in 59 patients, generating 19 pregnancies (32%), with an implantation rate of 19.9%.
conclusionsHigh rates of chromosomally abnormal embryos in poor-prognosis patients can determine repeated in vitro fertilization failures when embryo selection is performed on the basis of morphological criteria alone. Hence, the FISH analysis could represent the prevailing approach for the identification of embryos possessing full potential for developing to term.
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