ArticleJournal of assisted reproduction and genetics1998
Preimplantation diagnosis of common aneuploidies by the first- and second-polar body FISH analysis.
Article in Journal of assisted reproduction and genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 132 citations in OpenAlex.
- Single best euploid versus single best unknown-ploidy blastocyst frozen embryo transfers: a randomized controlled trial.Journal of assisted reproduction and genetics · 2019Trial
- Morphological assessment of oocyte quality during assisted reproductive technology cycle.JBRA assisted reproduction · 2024Review
- Mechanism of chromosomal mosaicism in preimplantation embryos and its effect on embryo development.Journal of assisted reproduction and genetics · 2024Review
- Exploring the Impact of Controlled Ovarian Stimulation and Non-Invasive Oocyte Assessment in ART Treatments.Life (Basel, Switzerland) · 2023Review
- Comment on the recent PGDIS Position Statement on the Transfer of Mosaic Embryos 2021.Journal of assisted reproduction and genetics · 2022Article
- Combining PGT-A with PGT-M risks trying to do too much.Journal of assisted reproduction and genetics · 2022Article
- Utilization of preimplantation genetic testing in the USA.Journal of assisted reproduction and genetics · 2021Article
- Depletion of aneuploid cells in human embryos and gastruloids.Nature cell biology · 2021Article
- A tale of two studies: now is no longer the best of times for preimplantation genetic testing for aneuploidy (PGT-A).Journal of assisted reproduction and genetics · 2020Article
- Preimplantation genetic testing for aneuploidy (PGT-A)-finally revealed.Journal of assisted reproduction and genetics · 2020Article
- The PGS/PGT-A controversy in IVF addressed as a formal conflict resolution analysis.Journal of assisted reproduction and genetics · 2020Article
- Expected advances in human fertility treatments and their likely translational consequences.Journal of translational medicine · 2018Review
- Is the hypothesis of preimplantation genetic screening (PGS) still supportable? A review.Journal of ovarian research · 2017Review
- Preimplantation genetic diagnosis: an update on current technologies and ethical considerations.Reproductive medicine and biology · 2016Review
- Age-related increase in aneuploidy and alteration of gene expression in mouse first polar bodies.Journal of assisted reproduction and genetics · 2014Article
- Chromosomes in the porcine first polar body possess competence of second meiotic division within enucleated MII stage oocytes.PloS one · 2013Article
- Preimplantation genetic diagnosis: state of the art 2011.Human genetics · 2012Review
- Preimplantation genetic testing: indications and controversies.Clinics in laboratory medicine · 2010Review
- Preimplantation diagnosis (PGD)--a European clinician's point of view.Journal of assisted reproduction and genetics · 2004Review
- FISH analysis of six chromosomes in unfertilized human oocytes after polar body removal.Journal of assisted reproduction and genetics · 2000Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeA low pregnancy rate in in vitro fertilization (IVF) patients of advanced maternal age may be caused by aneuploidies originating from non disjunction in the first or second meiotic divisions. We introduced genetic testing of oocytes by sampling and fluorescent in situ hybridization (FISH) analysis of the first and second polar bodies, to avoid fertilization and transfer of aneuploid oocytes in IVF patients of advanced maternal age.
methodsThree hundred and sixty-three IVF patients 34 years and older participated in the study. Using micromanipulation procedures, the first and second polar bodies were removed following their extrusion from the oocytes and studied by FISH, using probes specific for chromosomes 13, 18, and 21 to detect oocytes with common aneuploidies.
resultsOf a total of 538 IVF cycles, 3250 oocytes were available for FISH analysis, with conclusive FISH results in 2742 oocytes (84.3%). As many as 1102 (40%) of oocytes were predicted to be aneuploid and not transferred. Of 1640 embryos predicted to be normal, 1145 were transferred in 467 treatment cycles, resulting in 107 pregnancies (23%), from which 67 healthy children have been born, 32 pregnancies spontaneously aborted, and 15 pregnancies are ongoing after being confirmed normal by prenatal diagnosis.
conclusionsPreimplantation diagnosis by first- and second-polar body FISH analysis allows us to avoid the age-related risk of common aneuploidies in IVF patients of advanced maternal age.
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Registered trials
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