ArticleJournal of assisted reproduction and genetics1998
Chromosomal mosaicism in cleavage-stage human embryos and the accuracy of single-cell genetic analysis.
Article in Journal of assisted reproduction and genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 60 citations in OpenAlex.
- Cellular and Molecular Nature of Fragmentation of Human Embryos.International journal of molecular sciences · 2022Review
- Chromosomal instability in mammalian pre-implantation embryos: potential causes, detection methods, and clinical consequences.Cell and tissue research · 2016Review
- An overview of the available methods for morphological scoring of pre-implantation embryos in in vitro fertilization.Cell journal · 2015Review
- Mammalian pre-implantation chromosomal instability: species comparison, evolutionary considerations, and pathological correlations.Systems biology in reproductive medicine · 2015Review
- Preimplantation Genetic Diagnosis: Prenatal Testing for Embryos Finally Achieving Its Potential.Journal of clinical medicine · 2014Review
- Human pre-implantation embryo development.Development (Cambridge, England) · 2012Review
- Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage.Nature communications · 2012Article
- The single cell as a tool for genetic testing: credibility, precision, implication.Journal of assisted reproduction and genetics · 2010Article
- Molecular diagnostics in preimplantation genetic diagnosis.The Journal of molecular diagnostics : JMD · 2002Review
- Preimplantation genetic diagnosis in clinical practice.Journal of medical genetics · 2002Review
- Preimplantation genetics.Journal of assisted reproduction and genetics · 1998Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOur purpose was to assess the effect of chromosomal mosaicism in cleavage-stage human embryos on the accuracy of single-cell analysis for preimplantation genetic diagnosis.
methodsMulticolor fluorescence in situ hybridization with X, Y, and 7 or X, Y, 7, and 18 chromosome-specific probes was used to detect aneuploidy in cleavage-stage human embryos.
resultsMost nuclei were diploid for the chromosomes tested but there was extensive mosaicism including monosomic, double-monosomic, nullisomic, chaotic, and haploid nuclei.
conclusionsIdentification of sex by analysis of a single cleavage-stage nucleus is accurate but 7% of females are not identified. One or both parental chromosomes 7 were absent in at least 6.5% of the nuclei. With autosomal recessive conditions such as cystic fibrosis, carriers would be misdiagnosed as normal or affected. With autosomal dominant conditions, failure to analyze the affected parents allele (1.6-2.5%) would cause a serious misdiagnosis and analysis of at least two nuclei is necessary to reduce errors.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.