ArticleProceedings of the National Academy of Sciences of the United States of America1998
Identification of rat susceptibility loci for adjuvant-oil-induced arthritis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 117 citations in OpenAlex.
- Identification of Clec4b as a novel regulator of bystander activation of auto-reactive T cells and autoimmune disease.PLoS genetics · 2020Article
- Influence of hydrocarbon oil structure on adjuvanticity and autoimmunity.Scientific reports · 2017Article
- Adjuvants- and vaccines-induced autoimmunity: animal models.Immunologic research · 2017Article
- Rheumatoid arthritis: identifying and characterising polymorphisms using rat models.Disease models & mechanisms · 2016Review
- Identification of candidate risk gene variations by whole-genome sequence analysis of four rat strains commonly used in inflammation research.BMC genomics · 2014Article
- A 129-kb deletion on chromosome 12 confers substantial protection against rheumatoid arthritis, implicating the gene SLC2A3.Human mutation · 2014Article
- The early days of NK cells: an example of how a phenomenon led to detection of a novel immune receptor system - lessons from a rat model.Frontiers in immunology · 2014Review
- Identification of two new arthritis severity loci that regulate levels of autoantibodies, interleukin-1β, and joint damage in pristane- and collagen-induced arthritis.Arthritis and rheumatism · 2012Article
- Finemapping of the arthritis QTL Pia7 reveals co-localization with Oia2 and the APLEC locus.Genes and immunity · 2010Article
- A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice.Neurogenetics · 2010Article
- Gene-environment interaction between the DRB1 shared epitope and smoking in the risk of anti-citrullinated protein antibody-positive rheumatoid arthritis: all alleles are important.Arthritis and rheumatism · 2009Article
- The rat antigen-presenting lectin-like receptor complex influences innate immunity and development of infectious diseases.Genes and immunity · 2009Article
- The determinants of susceptibility/resistance to adjuvant arthritis in rats.Arthritis research & therapy · 2009Review
- Genetic and molecular basis of quantitative trait loci of arthritis in rat: genes and polymorphisms.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Contribution of genetic studies in rodent models of autoimmune arthritis to understanding and treatment of rheumatoid arthritis.Genes and immunity · 2007Review
- Cia25 on rat chromosome 12 regulates severity of autoimmune arthritis induced with pristane and with collagen.Annals of the rheumatic diseases · 2007Article
- Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis.Arthritis research & therapy · 2006Article
- Integrative genomics: in silico coupling of rat physiology and complex traits with mouse and human data.Genome research · 2004Article
- A comparative genetic analysis between collagen-induced arthritis and pristane-induced arthritis.Arthritis and rheumatism · 2003Article
- Neural immune pathways and their connection to inflammatory diseases.Arthritis research & therapy · 2003Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One intradermal injection of incomplete Freund's adjuvant-oil induces a T cell-mediated inflammatory joint disease in DA rats. Susceptibility genes for oil-induced arthritis (OIA) are located both within and outside the major histocompatibility complex (MHC, Oia1). We have searched for disease-linked non-MHC loci in an F2 intercross between DA rats and MHC-identical but arthritis-resistant LEW.1AV1 rats. A genome-wide scan with microsatellite markers revealed two major chromosome regions that control disease incidence and severity: Oia2 on chromosome 4 (P = 4 x 10(-13)) and Oia3 on chromosome 10 (P = 1 x 10(-6)). All animals homozygous for DA alleles at both loci developed severe arthritis, whereas all those homozygous for LEW.1AV1 alleles were resistant. These results have general implications for situations where nonspecific activation of the immune system (e.g., incomplete Freund's adjuvant-oil) causes inflammation and disease, either alone or in conjunction with specific antigens. They may also provide clues to the etiology of inflammatory diseases in humans, including rheumatoid arthritis.
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