ArticleProceedings of the National Academy of Sciences of the United States of America1998
Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independently in natural killer cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 125 citations in OpenAlex.
- Human lncRNAs NEAT1 and MALAT1 regulate the tumor microenvironment in lung cancer PDX models in athymic nude mice.Scientific reports · 2025Article
- Review
- Recent Advances in Molecular Mechanisms of the NKG2D Pathway in Hepatocellular Carcinoma.Biomolecules · 2020Review
- Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease.The Journal of clinical investigation · 2020Article
- Evidence of functional Cd94 polymorphism in a free-living house mouse population.Immunogenetics · 2019Article
- MICA and NKG2D: Is There an Impact on Kidney Transplant Outcome?Frontiers in immunology · 2017Review
- Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy.Nature communications · 2016Article
- NKG2D Receptor and Its Ligands in Host Defense.Cancer immunology research · 2015Review
- IFN-α-driven CCL2 production recruits inflammatory monocytes to infection site in mice.Mucosal immunology · 2013Article
- Natural killer cells: role in local tumor growth and metastasis.Biologics : targets & therapy · 2012Article
- Natural killer cells and their role in rheumatoid arthritis: friend or foe?TheScientificWorldJournal · 2012Review
- Regulation of immune cell function and differentiation by the NKG2D receptor.Cellular and molecular life sciences : CMLS · 2011Review
- Article
- Disruption of Th2 immunity results in a gender-specific expansion of IL-13 producing accessory NK cells during helminth infection.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- NK gene complex dynamics and selection for NK cell receptors.Seminars in immunology · 2008Review
- NKG2D ligands in tumor immunity.Oncogene · 2008Review
- Chicken CD69 and CD94/NKG2-like genes in a chromosomal region syntenic to mammalian natural killer gene complex.Immunogenetics · 2007Article
- The balancing act: inhibitory Ly49 regulate NKG2D-mediated NK cell functions.Seminars in immunology · 2006Review
- Natural killer cell immune responses.Immunologic research · 2005Review
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural killer (NK) cells express C-type lectin-like receptors, encoded in the NK gene complex, that interact with major histocompatibility complex class I and either inhibit or activate functional activity. Human NK cells express heterodimers consisting of CD94 and NKG2 family molecules, whereas murine NK cells express homodimers belonging to the Ly-49 family. The corresponding orthologues for other species, however, have not been described. In this report, we used probes derived from the expressed sequence tag database to clone C57BL/6-derived cDNAs homologous to human NKG2-D and CD94. Among normal tissues, murine NKG2-D and CD94 transcripts are highly expressed only in activated NK cells, including both Ly-49A+ and Ly-49A- subpopulations. Additionally, mNKG2-D is expressed in murine NK cell clones KY-1 and KY-2, whereas mCD94 expression is observed only in KY-1 cells but not KY-2. Last, we have finely mapped the physical location of the Cd94 (centromeric) and Nkg2d (telomeric) genes between Cd69 and the Ly49 cluster in the NK complex. Thus, these data indicate the expanding complexity of the NK complex and the corresponding repertoire of C-type lectin-like receptors on murine NK cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.