ArticleProceedings of the National Academy of Sciences of the United States of America1998
CIITA stimulation of transcription factor binding to major histocompatibility complex class II and associated promoters in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 69 citations in OpenAlex.
- Effects of early pregnancy on NOD-like receptor expression in the ovine endometrium.Frontiers in veterinary science · 2024Article
- The NLR member CIITA: Master controller of adaptive and intrinsic immunity and unexpected tool in cancer immunotherapy.Biomedical journal · 2023Review
- Structural aspects of the MHC expression control system.Biophysical chemistry · 2022Review
- Interferon Regulatory Factors 1 and 2 Play Different Roles in MHC II Expression Mediated by CIITA in Grass Carp,Frontiers in immunology · 2019Article
- NLRC5: a key regulator of MHC class I-dependent immune responses.Nature reviews. Immunology · 2012Review
- PML promotes MHC class II gene expression by stabilizing the class II transactivator.The Journal of cell biology · 2012Article
- NLRC5: a newly discovered MHC class I transactivator (CITA).Microbes and infection · 2012Review
- NLR family member NLRC5 is a transcriptional regulator of MHC class I genes.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- CATERPILLERs, pyrin and hereditary immunological disorders.Nature reviews. Immunology · 2006Review
- Bordetella pertussis infection of primary human monocytes alters HLA-DR expression.Infection and immunity · 2004Article
- Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation.Molecular and cellular biology · 2003Article
- Impaired regulation of HLA-DR expression in human immunodeficiency virus-infected monocytes.Clinical and diagnostic laboratory immunology · 2002Review
- A 36-amino-acid region of CIITA is an effective inhibitor of CBP: novel mechanism of gamma interferon-mediated suppression of collagen alpha(2)(I) and other promoters.Molecular and cellular biology · 2001Article
- Histone deacetylase activity represses gamma interferon-inducible HLA-DR gene expression following the establishment of a DNase I-hypersensitive chromatin conformation.Molecular and cellular biology · 2001Article
- Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes.Molecular and cellular biology · 2000Article
- Class II transactivator: mastering the art of major histocompatibility complex expression.Molecular and cellular biology · 2000Review
- Expression of MHC class II in T cells is associated with increased HIV-1 expression.Clinical and experimental immunology · 2000Article
- Transcriptional scaffold: CIITA interacts with NF-Y, RFX, and CREB to cause stereospecific regulation of the class II major histocompatibility complex promoter.Molecular and cellular biology · 2000Article
- CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex.Genes & development · 2000Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CIITA is a master transactivator of the major histocompatibility complex class II genes, which are involved in antigen presentation. Defects in CIITA result in fatal immunodeficiencies. CIITA activation is also the control point for the induction of major histocompatibility complex class II and associated genes by interferon-gamma, but CIITA does not bind directly to DNA. Expression of CIITA in G3A cells, which lack endogenous CIITA, followed by in vivo genomic footprinting, now reveals that CIITA is required for the assembly of transcription factor complexes on the promoters of this gene family, including DRA, Ii, and DMB. CIITA-dependent promoter assembly occurs in interferon-gamma-inducible cell types, but not in B lymphocytes. Dissection of the CIITA protein indicates that transactivation and promoter loading are inseparable and reveal a requirement for a GTP binding motif. These findings suggest that CIITA may be a new class of transactivator.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.