ArticleProceedings of the National Academy of Sciences of the United States of America1998
Submillimolar levels of calcium regulates DNA structure at the dinucleotide repeat (TG/AC)n.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Gene expression regulation by CaCellular & molecular biology letters · 2026Pooled it
- The unusual structural properties and potential biological relevance of switchback DNA.Nature communications · 2024Article
- The unusual structural properties and potential biological relevance of switchback DNA.bioRxiv : the preprint server for biology · 2024Article
- Physiology of intracellular calcium buffering.Physiological reviews · 2023Review
- Review
- The Role of Lamins in the Nucleoplasmic Reticulum, a Pleiomorphic Organelle That Enhances Nucleo-Cytoplasmic Interplay.Frontiers in cell and developmental biology · 2022Review
- Article
- Regulation of gene expression by NFAT transcription factors in hibernating ground squirrels is dependent on the cellular environment.Cell stress & chaperones · 2016Article
- Quantitative imaging of magnesium distribution at single-cell resolution in brain tumors and infiltrating tumor cells with secondary ion mass spectrometry (SIMS).Journal of neuro-oncology · 2016Article
- Article
- The interplay of transcription factors in suppression of UV-B induced flavonol accumulation by flg22.Plant signaling & behavior · 2014Article
- Great insight created by tiny holes; celebrating 40 years of brain micropunch technique.Frontiers in neuroanatomy · 2014Article
- Nucleoplasmic calcium signaling and cell proliferation: calcium signaling in the nucleus.Cell communication and signaling : CCS · 2013Article
- GMO detection using a bioluminescent real time reporter (BART) of loop mediated isothermal amplification (LAMP) suitable for field use.BMC biotechnology · 2012Article
- The molecular identity of the mitochondrial Ca2+ sequestration system.The FEBS journal · 2010Review
- Physical plasticity of the nucleus and its manipulation.Methods in cell biology · 2010Review
- Nuclear calcium signaling: a cell within a cell.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2009Review
- Power-law rheology of isolated nuclei with deformation mapping of nuclear substructures.Biophysical journal · 2005Article
- Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum.Nature cell biology · 2003Article
- CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Submillimolar levels of calcium, similar to the physiological total (bound + free) intranuclear concentration (0.01-1 mM), induced a conformational change within d(TG/AC)n, one of the frequent dinucleotide repeats of the mammalian genome. This change is calcium-specific, because no other tested cation induced it and it was detected as a concentration-dependent transition from B- to a non-B-DNA conformation expanding from 3' end toward the 5' of the repeat. Genomic footprinting of various rat brain regions revealed the existence of similar non-B-DNA conformation within a d(TG/AC)28 repeat of the endogenous enkephalin gene only in enkephalin-expressing caudate nucleus and not in the nonexpressing thalamus. Binding assays demonstrated that DNA could bind calcium and can compete with calmodulin for calcium.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.