ArticleAmerican journal of human genetics1998
Simple, robust linkage tests for affected sibs.
Article in American journal of human genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- A Rare Variant Nonparametric Linkage Method for Nuclear and Extended Pedigrees with Application to Late-Onset Alzheimer Disease via WGS Data.American journal of human genetics · 2019Article
- A statistical approach for rare-variant association testing in affected sibships.American journal of human genetics · 2015Article
- Using parental phenotypes in case-parent studies.Frontiers in genetics · 2015Article
- ALPK1 genetic regulation and risk in relation to gout.International journal of epidemiology · 2013Article
- The null distribution of likelihood-ratio statistics in the conditional-logistic linkage model.Frontiers in genetics · 2013Article
- Some capabilities for model-based and model-free linkage analysis using the program package S.A.G.E. (Statistical Analysis for Genetic Epidemiology).Human heredity · 2011Article
- Linkage analysis in the next-generation sequencing era.Human heredity · 2011Review
- Variance component model to account for sample structure in genome-wide association studies.Nature genetics · 2010Article
- Linkage analysis of schizophrenia in African-American families.Schizophrenia research · 2009Article
- Finding genes underlying human disease.Clinical genetics · 2009Review
- Genetic model selection in two-phase analysis for case-control association studies.Biostatistics (Oxford, England) · 2008Article
- Testing genetic linkage with relative pairs and covariates by quasi-likelihood score statistics.Human heredity · 2007Article
- A novel framework for sib pair linkage analysis.American journal of human genetics · 2006Article
- A quantitative linkage score for an association study following a linkage analysis.BMC genetics · 2006Article
- Genetic linkage of systemic lupus erythematosus to 13q32 in African American families with affected male members.Human genetics · 2005Article
- Weighting affected sib pairs by marker informativity.American journal of human genetics · 2005Article
- Intracranial aneurysms in Finnish families: confirmation of linkage and refinement of the interval to chromosome 19q13.3.American journal of human genetics · 2004Article
- Comparison of significance level at the true location using two linkage approaches: LODPAL and GENEFINDER.BMC genetics · 2003Article
- A genome screen of systemic lupus erythematosus using affected-relative-pair linkage analysis with covariates demonstrates genetic heterogeneity.Genes and immunity · 2002Article
- A second locus for very-late-onset Alzheimer disease: a genome scan reveals linkage to 20p and epistasis between 20p and the amyloid precursor protein region.American journal of human genetics · 2002Article
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2 authors.
Funding
Abstract
Parametric-linkage analysis applied to large pedigrees with many affected individuals has helped in the identification of highly penetrant genes; but, for diseases lacking a clear Mendelian inheritance pattern or caused by several genes of low to moderate penetrance, a more robust strategy is nonparametric analysis applied to small sets of affected relatives, such as affected sib pairs. Here we show that the robustness of affected-sib-pair tests is related to the shape of the constraint set for the sibs' identity-by-descent (IBD) probabilities. We also derive a set of constraints for the IBD probabilities of affected sib triples and use common features of the shapes of the two constrain sets to introduce new nonparametric tests (called "minmax" tests) that are more robust than those in current use. Asymptotic-power computations support the robustness of the proposed minmax tests.
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