Evidence map›Paper›PMID 9596784›Full record

ArticleInfection and immunity1998

Clearance of Shigella flexneri infection occurs through a nitric oxide-independent mechanism.

S S Way, M B Goldberg

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Bioenergetics and Reactive Nitrogen Species in Bacteria.International journal of molecular sciences · 2022
    Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

S S WayDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
M B Goldberg
Albert Einstein College of Medicine · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
MECHANISM AND FUNCTION OF UNIPOLARITY OF SHIGELLA ICSAR01AI035817 · NIAID · YESHIVA UNIVERSITY · PI GOLDBERG, MARCIA B · 1994 to 2009
$3.9M
NIAID NIH HHS AI35817NIAID NIH HHS R01 AI035817NIGMS NIH HHS T32 GM007288NIGMS NIH HHS T32 GM07288
6 · The paper itself

Abstract

Nitric oxide (NO) generated by gamma interferon (IFN-gamma) activation of macrophages mediates the killing of many intracellular pathogens. IFN-gamma is essential to innate resistance to Shigella flexneri infection. We demonstrate that NO is produced following S. flexneri infection both in mice and in activated cells in vitro and that while it is able to kill S. flexneri in a cell-free system, it is not required for clearance of S. flexneri in either infected mice or in activated cells in vitro.

Indexed as

AnimalsGuanidinesInterferon-gammaLipopolysaccharidesMacrophage ActivationMiceMice, Inbred C57BLMice, Mutant StrainsNitratesNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IINitritesRespiratory Tract InfectionsShigella flexneriGuanidinesInterferon-gammaLipopolysaccharidesNitratesNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IINitritesNos2 protein, mousepimagedine

Identifiers

PMID9596784
PMCPMC108306
OpenAlexW2125656439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.