ArticleInfection and immunity1998
Experimental Helicobacter pylori infection induces antral gastritis and gastric mucosa-associated lymphoid tissue in guinea pigs.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 56 citations in OpenAlex.
- Managing dangerous liaisons: lessons fromJournal of bacteriology · 2026Review
- Establishment of an intragastric surgical model using C57BL/6 mice to study the vaccine efficacy of OMV-based immunogens against Helicobacter pylori.Biology open · 2025Article
- A critical review onFrontiers in cellular and infection microbiology · 2025Review
- Animal Models andJournal of clinical medicine · 2022Review
- Dietary factors modulate Helicobacter-associated gastric cancer in rodent models.Toxicologic pathology · 2014Article
- Gastritis induced by Helicobacter pylori infection in experimental rats.Digestive diseases and sciences · 2010Article
- Pathogenesis of Helicobacter pylori infection.Clinical microbiology reviews · 2006Review
- Lectin histochemistry of the gastric mucosa in normal and Helicobacter pylori infected guinea-pigs.Journal of molecular histology · 2005Article
- Helicobacter-induced chronic active lymphoid aggregates have characteristics of tertiary lymphoid tissue.Infection and immunity · 2003Article
- Rapid genetic analysis of Helicobacter pylori gastric mucosal colonization in suckling mice.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Comparative analysis of colonization of Helicobacter pylori and glycolipids receptor density in Mongolian gerbils and mice.Digestive diseases and sciences · 2001Article
- Emergence of diverse Helicobacter species in the pathogenesis of gastric and enterohepatic diseases.Clinical microbiology reviews · 2001Review
- Isolation and characterization of a Helicobacter sp. from the gastric mucosa of dolphins, Lagenorhynchus acutus and Delphinus delphis.Applied and environmental microbiology · 2000Article
- Helicobacter pylori-associated gastritis in mice is host and strain specific.Infection and immunity · 1999Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Humans infected with Helicobacter pylori have abnormally low levels of the antioxidant vitamin C, which protects against the formation of carcinogenic nitrosamines, in gastric juice. Guinea pigs, like humans and nonhuman primates, have a dietary requirement for vitamin C. As such, these species have gastrointestinal vitamin C transport systems not found in other animals. We have developed and characterized a guinea pig model of chronic gastric H. pylori infection with the rodent-adapted Sydney strain of H. pylori. At 4 weeks postinfection, five of six animals of the infected group and zero of two animals of the control group were positive for H. pylori as determined by culture or PCR. At 15 weeks, six of six animals of the infected group and zero of two animals of the control group were positive. H. pylori-specific seroconversion was observed among infected animals. There were no histologic abnormalities in the gastric antra or fundi of control guinea pigs. In contrast, there was multifocal, mild to moderate lymphohistiocytic antral gastritis and formation of antral lymphoid follicles in H. pylori-infected animals. The lesion distribution in the gastric antra paralleled that observed in H. pylori-infected humans. The H. pylori-infected guinea pig should prove useful in modeling the interaction of helicobacter and vitamin C in gastric carcinogenesis.
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Registered trials
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