ArticleInfection and immunity1998
Analysis of host cells associated with the Spv-mediated increased intracellular growth rate of Salmonella typhimurium in mice.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 78 citations in OpenAlex.
- Human Salmonellosis: A Continuous Global Threat in the Farm-to-Fork Food Safety Continuum.Foods (Basel, Switzerland) · 2023Review
- Characterization of virulence factors of Salmonella isolated from human stools and street food in urban areas of Burkina Faso.BMC microbiology · 2021Article
- Pathoadaptation of the passerine-associated Salmonella enterica serovar Typhimurium lineage to the avian host.PLoS pathogens · 2021Article
- Virulence Factors in Salmonella Typhimurium: The Sagacity of a Bacterium.Current microbiology · 2019Review
- Dietary Antigens Induce Germinal Center Responses in Peyer's Patches and Antigen-Specific IgA Production.Frontiers in immunology · 2019Article
- Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling.The Journal of experimental medicine · 2018Article
- IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake.The Journal of experimental medicine · 2017Article
- Allograft inflammatory factor 1 is a regulator of transcytosis in M cells.Nature communications · 2017Article
- Virulence Characterisation of Salmonella enterica Isolates of Differing Antimicrobial Resistance Recovered from UK Livestock and Imported Meat Samples.Frontiers in microbiology · 2016Article
- Article
- Evaluation of the live vaccine efficacy of virulence plasmid-cured, and phoP- or aroA-deficient Salmonella enterica serovar Typhimurium in mice.The Journal of veterinary medical science · 2015Article
- Salmonella Typhimurium exploits inflammation to its own advantage in piglets.Frontiers in microbiology · 2015Article
- Salmonella pathogenicity and host adaptation in chicken-associated serovars.Microbiology and molecular biology reviews : MMBR · 2013Review
- The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells.Nature immunology · 2012Article
- Pathogenicity of Salmonella enterica in Caenorhabditis elegans relies on disseminated oxidative stress in the infected host.PloS one · 2012Article
- Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.Nature · 2009Article
- During infection of epithelial cells Salmonella enterica serovar Typhimurium undergoes a time-dependent transcriptional adaptation that results in simultaneous expression of three type 3 secretion systems.Cellular microbiology · 2008Article
- Comparative efficacies of different antibiotic treatments to eradicate nontypeable Haemophilus influenzae infection.BMC infectious diseases · 2008Article
- Analysis of cells targeted by Salmonella type III secretion in vivo.PLoS pathogens · 2007Article
- Transcription modulation of Salmonella enterica serovar Typhimurium promoters by sub-MIC levels of rifampin.Journal of bacteriology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The 90-kb virulence plasmid of Salmonella typhimurium encodes five spv genes which increase the growth rate of the bacteria within host cells within the first week of systemic infection of mice (P. A. Gulig and T. J. Doyle, Infect. Immun. 61:504-511, 1993). The presently described study was aimed at identifying the host cells associated with Spv-mediated virulence by manipulating the mouse host and the salmonellae. To test the effects of T cells and B cells on the Spv phenotype, salmonellae were orally inoculated into nude and SCID BALB/c mice. Relative to normal BALB/c mice, nude and SCID BALB/c mice were unaffected for splenic infection with either the Spv+ or Spv- S. typhimurium strains at 5 days postinoculation. When mice were pretreated with cyclophosphamide to induce granulocytopenia, there was a variable increase in total salmonella infection, but the relative splenic CFU of Spv+ versus Spv- S. typhimurium was not changed after oral inoculation. In contrast, depletion of macrophages from mice by treatment with cyclophosphamide plus liposomes containing dichloromethylene diphosphate resulted in equivalent virulence of Spv+ and Spv- salmonellae. To examine if the spv genes affected the growth of salmonellae in nonphagocytic cells, an invA::aphT mutation was transduced into Spv+ and Spv- S. typhimurium strains. InvA- Spv+ salmonellae were not significantly affected for splenic infection after subcutaneous inoculation compared with the wild-type strain, and InvA- Spv- salmonellae were only slightly attenuated relative to InvA+ Spv- salmonellae. Invasion-defective salmonellae still exhibited the Spv phenotype. Therefore, infection of nonphagocytes is not involved with the Spv virulence function. Taken together, these data demonstrate that macrophages are essential for suppressing the infection by Spv- S. typhimurium, by serving as the primary host cell for Spv-mediated intracellular replication and possibly by inhibiting the replication of salmonellae within other macrophages.
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