ArticleThe Journal of clinical investigation1998
A pathogenetic role for the thymoma in myasthenia gravis. Autosensitization of IL-4- producing T cell clones recognizing extracellular acetylcholine receptor epitopes presented by minority class II isotypes.
Article in The Journal of clinical investigation, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 78 citations in OpenAlex.
- Immunological Targets in Generalized Myasthenia Gravis Treatment: Where Are We Going Now?Brain sciences · 2025Review
- Fc-Receptor Targeted Therapies for the Treatment ofInternational journal of molecular sciences · 2021Review
- Thymus and autoimmunity.Seminars in immunopathology · 2021Review
- Review
- Serum cytokine and chemokine profiles in patients with myasthenia gravis.Clinical and experimental immunology · 2014Article
- CTLA4 variants and haplotype contribute genetic susceptibility to myasthenia gravis in northern Chinese population.PloS one · 2014Article
- Immune-mediated diseases and immunodeficiencies associated with thymic epithelial neoplasms.Journal of clinical immunology · 2012Article
- The etiology of paraneoplastic autoimmunity.Clinical reviews in allergy & immunology · 2012Review
- Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1.PLoS medicine · 2006Article
- Anti-cytokine autoantibodies in autoimmunity: preponderance of neutralizing autoantibodies against interferon-alpha, interferon-omega and interleukin-12 in patients with thymoma and/or myasthenia gravis.Clinical and experimental immunology · 2003Article
- A role for CD36 in the regulation of dendritic cell function.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Altered T cell development in human thymoma is related to impairment of MHC class II transactivator expression induced by interferon-gamma (IFN-gamma).Clinical and experimental immunology · 2000Article
- Potent immunostimulatory dendritic cells can be cultured in bulk from progenitors in normal infant and adult myasthenic human thymus.Immunology · 1999Article
- Antibodies to ion channels in paraneoplastic disorders.Brain pathology (Zurich, Switzerland) · 1999Review
- Immunological system status and the appearance of respiratory system disturbances in thymectomized patients.Archivum immunologiae et therapiae experimentalisArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myasthenia gravis (MG) is caused by helper T cell-dependent autoantibodies against the muscle acetylcholine receptor (AChR). Thymic epithelial tumors (thymomas) occur in 10% of MG patients, but their autoimmunizing potential is unclear. They express mRNAs encoding AChR alpha and epsilon subunits, and might aberrantly select or sensitize developing thymocytes or recirculating peripheral T cells against AChR epitopes. Alternatively, there could be defective self-tolerance induction in the abundant maturing thymocytes that they usually generate. For the first time, we have isolated and characterized AChR-specific T cell clones from two MG thymomas. They recognize extracellular epitopes (alpha75-90 and alpha149-158) which are processed very efficiently from muscle AChR. Both clones express CD4 and CD8alpha, and have a Th-0 cytokine profile, producing IL-4 as well as IFN-gamma. They are restricted to HLA-DP14 and DR52a; expression of these minority isotypes was strong on professional antigen-presenting cells in the donors' tumors, although it is generally weak in the periphery. The two clones' T cell receptor beta chains are different, but their alpha chain sequences are very similar. These resemblances, and the striking contrasts with T cells previously cloned from non-thymoma patients, show that thymomas generate and actively induce specific T cells rather than merely failing to tolerize them against self antigens.
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