ArticleThe Journal of clinical investigation1998
Role of nitric oxide and peroxynitrite in the cytokine-induced sustained myocardial dysfunction in dogs in vivo.
Article in The Journal of clinical investigation, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 114 citations in OpenAlex.
- Hyperthermia by bathing in a hot spring improves cardiovascular functions and reduces the production of inflammatory cytokines in patients with chronic heart failure.Heart and vessels · 2013Trial
- Simvastatin attenuates leucocyte-endothelial interactions after coronary revascularisation with cardiopulmonary bypass.Heart (British Cardiac Society) · 2003Trial
- Heavy Metal Exposure-induced Cardiovascular Diseases: Molecular Mechanisms and Therapeutic Role of Antioxidants.Current medicinal chemistry · 2025Review
- Involvement of kallikrein-PAR2-proinflammatory pathway in severe trastuzumab-induced cardiotoxicity.Cancer science · 2022Article
- Human cardiac organoids to model COVID-19 cytokine storm induced cardiac injuries.Journal of tissue engineering and regenerative medicine · 2022Article
- Human Cardiac Organoids to Model COVID-19 Cytokine Storm Induced Cardiac Injuries.bioRxiv : the preprint server for biology · 2022Article
- SGLT2 inhibitor dapagliflozin prevents atherosclerotic and cardiac complications in experimental type 1 diabetes.PloS one · 2022Article
- Review
- Trichosanthis Pericarpium Aqueous Extract Protects H9c2 Cardiomyocytes from Hypoxia/Reoxygenation Injury by Regulating PI3K/Akt/NO Pathway.Molecules (Basel, Switzerland) · 2018Article
- Proinflammatory Cytokines Mediate GPCR Dysfunction.Journal of cardiovascular pharmacology · 2017Review
- Oxidative stress markers and C-reactive protein are related to severity of heart failure in patients with dilated cardiomyopathy.Mediators of inflammation · 2014Article
- Differential effects of selective and non-selective nitric oxide synthase inhibitors on the blood perfusion of ischemia-reperfused myocardium in dogs.Medical science monitor basic research · 2013Article
- Quercetin reduces inflammatory responses in LPS-stimulated cardiomyoblasts.Oxidative medicine and cellular longevity · 2012Article
- Toll-like receptor and its roles in myocardial ischemic/reperfusion injury.Medical science monitor : international medical journal of experimental and clinical research · 2011Review
- Role of nitric oxide and its metabolites as potential markers in lung cancer.Annals of thoracic medicine · 2010Article
- Effects of tamoxifen on myocardial ischemia-reperfusion injury model in ovariectomized rats.Molecular and cellular biochemistry · 2008Article
- Nitric oxide and peroxynitrite in health and disease.Physiological reviews · 2007Review
- Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats.British journal of pharmacology · 2006Article
- Abnormalities in nitric oxide and its derivatives in lung cancer.American journal of respiratory and critical care medicine · 2005Article
- Role of tumour necrosis factor-alpha and other cytokines in ischemia-reperfusion-induced injury in the heart.Experimental and clinical cardiology · 2005Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies in vitro suggested that inflammatory cytokines could cause myocardial dysfunction. However, the detailed mechanism for the cytokine-induced myocardial dysfunction in vivo remains to be examined. We thus examined this point in our new canine model in vivo, in which microspheres with and without IL-1beta were injected into the left main coronary artery. Left ventricular ejection fraction (LVEF) was evaluated by echocardiography for 1 wk. Immediately after the microsphere injection, LVEF decreased to approximately 30% in both groups. While LVEF rapidly normalized in 2 d in the control group, it was markedly impaired in the IL-1beta group even at day 7. Pretreatment with dexamethasone or with aminoguanidine, an inhibitor of inducible nitric oxide synthase, prevented the IL-1beta-induced myocardial dysfunction. Nitrotyrosine concentration, an in vivo marker of the peroxynitrite production by nitric oxide and superoxide anion, was significantly higher in the myocardium of the IL-1beta group than in that of the control group or the group cotreated with dexamethasone or aminoguanidine. There was an inverse linear relationship between myocardial nitrotyrosine concentrations and LVEF. These results indicate that IL-1beta induces sustained myocardial dysfunction in vivo and that nitric oxide produced by inducible nitric oxide synthase and the resultant formation of peroxynitrite are substantially involved in the pathogenesis of the cytokine-induced sustained myocardial dysfunction in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.