ArticleAntimicrobial agents and chemotherapy1998
Photoaffinity analog of the semisynthetic echinocandin LY303366: identification of echinocandin targets in Candida albicans.
Article in Antimicrobial agents and chemotherapy, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- CRS-MIS in Candida glabrata: sphingolipids modulate echinocandin-Fks interaction.Molecular microbiology · 2012Article
- Topological and mutational analysis of Saccharomyces cerevisiae Fks1.Eukaryotic cell · 2012Article
- Occidiofungin's chemical stability and in vitro potency against Candida species.Antimicrobial agents and chemotherapy · 2012Article
- Article
- Discovery of a novel class of orally active antifungal beta-1,3-D-glucan synthase inhibitors.Antimicrobial agents and chemotherapy · 2011Article
- New Fks hot spot for acquired echinocandin resistance in Saccharomyces cerevisiae and its contribution to intrinsic resistance of Scedosporium species.Antimicrobial agents and chemotherapy · 2011Article
- Current perspectives on echinocandin class drugs.Future microbiology · 2011Review
- The Candida albicans Sur7 protein is needed for proper synthesis of the fibrillar component of the cell wall that confers strength.Eukaryotic cell · 2011Article
- The Sur7 protein regulates plasma membrane organization and prevents intracellular cell wall growth in Candida albicans.Molecular biology of the cell · 2008Article
- Resistance to echinocandin-class antifungal drugs.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2007Review
- The echinocandin "target" identified by cross-linking is a homolog of Pil1 and Lsp1, sphingolipid-dependent regulators of cell wall integrity signaling.Antimicrobial agents and chemotherapy · 2004Article
- Bgs3p, a putative 1,3-beta-glucan synthase subunit, is required for cell wall assembly in Schizosaccharomyces pombe.Eukaryotic cell · 2003Article
- A glucan synthase FKS1 homolog in cryptococcus neoformans is single copy and encodes an essential function.Journal of bacteriology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The echinocandins are a family of cyclic lipopeptides with potent antifungal activity. These compounds inhibit the synthesis of BETA-1,3-glucan in fungi. The new semisynthetic echinocandin LY303366 was derivatized to produce a photoactivatable cross-linking echinocandin analog with antifungal activity. This analog was radioiodinated and used as a probe in microsomal membrane preparations of Candida albicans which contain glucan synthase activity. The photoaffinity probe identified two major proteins of 40 and 18 kDa in both membrane preparations. Labeling of these proteins was specific in that it required irradiation with UV light and was effectively competed against with unlabeled echinocandin analogs. In addition, the abilities of echinocandin analogs to compete with the photoaffinity probe correlated to their relative antifungal potencies and glucan synthase inhibition. The 40-kDa protein was isolated, and partial sequences were obtained from internal peptide fragments of the protein. Analysis of the sequences of these internal peptides of the 40-kDa protein revealed that it was a new protein not previously described as being involved in glucan synthesis or the mode of action of echinocandins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.