ArticleNucleic acids research1998
MALDI-TOF mass spectrometric typing of single nucleotide polymorphisms with mass-tagged ddNTPs.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Label-free microarray imaging for direct detection of DNA hybridization and single-nucleotide mismatches.Biosensors & bioelectronics · 2010Article
- Liquid chromatography-electrospray ionization mass spectrometry for simultaneous detection of mtDNA length and nucleotide polymorphisms.International journal of legal medicine · 2007Article
- Parallel minisequencing followed by multiplex matrix-assisted laser desorption/ionization mass spectrometry assay for beta-thalassemia mutations.Journal of human genetics · 2005Article
- Digital detection of genetic mutations using SPC-sequencing.Genome research · 2004Article
- A novel MALDI-TOF based methodology for genotyping single nucleotide polymorphisms.Nucleic acids research · 2003Article
- Photocleavage of a 2-nitrobenzyl linker bridging a fluorophore to the 5' end of DNA.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Fragmentation pathway studies of oligonucleotides in matrix-assisted laser desorption/ionization mass spectrometry by charge tagging and H/D exchange.Journal of the American Society for Mass Spectrometry · 2002Article
- Solid phase capturable dideoxynucleotides for multiplex genotyping using mass spectrometry.Nucleic acids research · 2002Article
- Single nucleotide polymorphism seeking long term association with complex disease.Nucleic acids research · 2002Article
- Validation of DNA sequences using mass spectrometry coupled with nucleoside mass tagging.Genome research · 2002Article
- Evaluation of sample preparation techniques for mass measurements of PCR products using ESI-FT-ICR mass spectrometry.Journal of the American Society for Mass Spectrometry · 2002Article
- Hierarchical high-throughput SNP genotyping of the human Y chromosome using MALDI-TOF mass spectrometry.Nucleic acids research · 2002Article
- DNA sequencing using biotinylated dideoxynucleotides and mass spectrometry.Nucleic acids research · 2001Article
- Rapid characterization of DNA oligomers and genotyping of single nucleotide polymorphism using nucleotide-specific mass tags.Nucleic acids research · 2001Article
- A new MALDI-TOF based mini-sequencing assay for genotyping of SNPS.Nucleic acids research · 2000Article
- A novel procedure for efficient genotyping of single nucleotide polymorphisms.Nucleic acids research · 2000Article
- DNA sequence analysis by hybridization with oligonucleotide microchips: MALDI mass spectrometry identification of 5mers contiguously stacked to microchip oligonucleotides.Nucleic acids research · 2000Article
- Direct genetic analysis by matrix-assisted laser desorption/ionization mass spectrometry.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
A matrix-assisted laser desorption/ionization time-of-flight mass spectrometry based method has recently been reported for the typing of single nucleotide polymorphisms using single nucleotide primer extension. This method is limited in some cases by the resolution of the mass determination, as the mass difference between nucleotides can be as little as 9 Da (the difference between A and T). A variation of this method is described here in which a mass-tagged dideoxynucleotide is employed in the primer extension reactions in place of the unmodified dideoxynucleotide. The increased mass difference due to the presence of the mass-tags substantially improves the accuracy and versatility of the procedure.
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