ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Divergence in the expression of molecular markers of neuronal activation in the parvocellular paraventricular nucleus of the hypothalamus evoked by alcohol administration via different routes.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed, 71 citations in OpenAlex.
- Synaptic Effects Induced by Alcohol.Current topics in behavioral neurosciences · 2025Review
- Association between Alcohol Consumption and Serum Cortisol Levels: a Mendelian Randomization Study.Journal of Korean medical science · 2021Article
- SIRT1 Mediates Neuropathic Pain Induced by Sciatic Nerve Chronic Constrictive Injury in the VTA-NAc Pathway.Pain research & management · 2020Article
- Hypothalamic neuropeptide signaling in alcohol addiction.Progress in neuro-psychopharmacology & biological psychiatry · 2016Review
- Preclinical evidence implicating corticotropin-releasing factor signaling in ethanol consumption and neuroadaptation.Genes, brain, and behavior · 2015Review
- Alcohol, stress hormones, and the prefrontal cortex: a proposed pathway to the dark side of addiction.Neuroscience · 2014Review
- Adolescent alcohol exposure alters the rat adult hypothalamic-pituitary-adrenal axis responsiveness in a sex-specific manner.Neuroscience · 2013Article
- Synaptic effects induced by alcohol.Current topics in behavioral neurosciences · 2013Review
- c-Fos immunoreactivity in prefrontal, basal ganglia and limbic areas of the rat brain after central and peripheral administration of ethanol and its metabolite acetaldehyde.Frontiers in behavioral neuroscience · 2013Article
- Urocortins: CRF's siblings and their potential role in anxiety, depression and alcohol drinking behavior.Alcohol (Fayetteville, N.Y.) · 2012Review
- Neuropeptide Y signaling modulates the expression of ethanol-induced behavioral sensitization in mice.Addiction biology · 2012Article
- Adolescent alcohol exposure alters the central brain circuits known to regulate the stress response.Neuroscience · 2011Article
- Binge-pattern alcohol exposure during puberty induces long-term changes in HPA axis reactivity.PloS one · 2011Article
- Urocortins are present in the rat testis.Neuropeptides · 2011Article
- Differential effects of acute and chronic ethanol exposure on orexin expression in the perifornical lateral hypothalamus.Alcoholism, clinical and experimental research · 2010Article
- Microarray analysis identifies cerebellar genes sensitive to chronic ethanol treatment in PKCgamma mice.Alcohol (Fayetteville, N.Y.) · 2006Article
- Addiction-prone Lewis but not Fischer rats develop compulsive running that coincides with downregulation of nerve growth factor inducible-B and neuron-derived orphan receptor 1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immediate early gene (IEG) expression has been routinely used by neuroscientists as an index of neuronal activation. In the case of the hypothalamic-pituitary-adrenal axis, induction of c-fos and/or NGFI-B mRNAs in the parvocellular paraventricular nucleus (pPVN) has been documented after a variety of stimuli that increase adrenocorticotropin (ACTH) in the systemic circulation. However, the functional relationship between expression of IEGs and transcription of the genes for the ACTH secretagogues corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) is not clear. While investigating the neuroendocrine correlates of alcohol administration via different routes (intraperitoneal vs intragastric), we noted a difference in the time course of NGFI-B mRNA expression in the pPVN, despite comparable dynamics in ACTH secretion. By comparing the temporal cascade of transcriptional events in vivo after alcohol injection via either route, we sought to determine functional relationships between IEGs and the induction of CRF and AVP heteronuclear RNAs (hnRNAs). One advantage of our paradigm is the use of the same stimulus (systemic alcohol injection) in which access to the CNS does not differ between the groups to be compared. Intraperitoneal administration of the drug resulted in significant increases in c-fos mRNA, Fos protein, CRF hnRNA, and AVP hnRNA. In contrast, intragastric treatment evoked a brief, modest elevation in c-fos mRNA and Fos protein, increased AVP hnRNA, and caused no detectable change in CRF hnRNA. These data indicate that robust increases in CRF hnRNA are closely linked to full expression of c-fos mRNA and Fos protein. In addition, the expression of NGFI-B after both routes of administration is indicative of cellular activation within the pPVN in parallel with secretion of ACTH.
Indexed as
Identifiers
9592111PMC6792808W2146532169What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.