ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Expression of integrin-associated protein gene associated with memory formation in rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
- Novel role of NCoR1 in impairing spatial memory through the mediation of a novel interacting protein DEC2.Cellular and molecular life sciences : CMLS · 2024Article
- Structural-functional diversity of CD47 proteoforms.Frontiers in immunology · 2024Review
- The Potential Role of Integrin Signaling in Memory and Cognitive Impairment.Biomolecules · 2023Review
- Article
- Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits.PLoS genetics · 2020Article
- IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells.Stem cell reports · 2017Article
- Galectin-3 Negatively Regulates Hippocampus-Dependent Memory Formation through Inhibition of Integrin Signaling and Galectin-3 Phosphorylation.Frontiers in molecular neuroscience · 2017Article
- Integrin-associated protein promotes neuronal differentiation of neural stem/progenitor cells.PloS one · 2015Article
- Article
- NBM-T-L-BMX-OS01, Semisynthesized from Osthole, Is a Novel Inhibitor of Histone Deacetylase and Enhances Learning and Memory in Rats.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Integrins as receptor targets for neurological disorders.Pharmacology & therapeutics · 2012Review
- The absence of CD47 promotes nerve fiber growth from cultured ventral mesencephalic dopamine neurons.PloS one · 2012Article
- Laminin-β1 impairs spatial learning through inhibition of ERK/MAPK and SGK1 signaling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Novel role and mechanism of protein inhibitor of activated STAT1 in spatial learning.The EMBO journal · 2011Article
- Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration.BMC neuroscience · 2010Article
- Establishment of an early liver fibrosis model by the hydrodynamics-based transfer of TGF-beta1 gene.Comparative hepatology · 2007Article
- CD47 promotes neuronal development through Src- and FRG/Vav2-mediated activation of Rac and Cdc42.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Distinct roles of the beta 1-class integrins at the developing and the mature hippocampal excitatory synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Promotion of neurite and filopodium formation by CD47: roles of integrins, Rac, and Cdc42.Molecular biology of the cell · 2004Article
- Integrin requirement for hippocampal synaptic plasticity and spatial memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study has adopted the PCR differential display method to identify cDNA clones associated with memory formation in rats. The one-way inhibitory avoidance learning task was used as the behavioral paradigm. Total RNA isolated from the hippocampus of poor-memory (<80 sec) and good-memory (600 sec) rats 3 hr after training was used for comparison. Three cDNA fragments corresponding to different spliced forms of integrin-associated protein (IAP) mRNA were found to be differentially expressed in the hippocampus of good-memory rats. Quantitative reverse transcription-PCR revealed approximately four fold higher of IAP mRNA level in good-memory rats. This result was confirmed further by in situ hybridization analysis, and the major difference was in the dentate gyrus. It has been demonstrated that this difference in IAP mRNA expression is not attributable to different sensitivities of individual rats to electric shock. Rapid amplification of cDNA ends obtained the full-length IAP cDNA, which is 1192 bp in length excluding the poly(A+) tail. The IAP mRNA expression was significantly upregulated by NMDA and amphetamine injections to the dentate gyrus of the hippocampus. On the other hand, injection of antisense oligonucleotide complementary to the IAP transcript markedly impaired memory retention in rats and decreased the amplitude and slope of EPSP in the in vivo long-term potentiation paradigm. These results together suggest that IAP gene expression plays an important role in memory formation and synaptic plasticity in rat hippocampus.
Indexed as
Identifiers
9592107PMC6792811W2142664907What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.