ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Seizure-induced neuronal injury: vulnerability to febrile seizures in an immature rat model.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
88 citing papers in PubMed, 276 citations in OpenAlex.
- Sex-specific interneuron vulnerability after traumatic brain injury correlates with neurotrophic signaling and chloride homeostasis, independent of behavioral and network outcomes.Frontiers in cellular neuroscience · 2025Article
- Changes in Hippocampal Volume after Traumatic Brain Injury (TBI).Research square · 2024Article
- Review
- Increased thrombospondin-1 levels contribute to epileptic susceptibility in neonatal hyperthermia without seizures via altered synaptogenesis.Cell death discovery · 2024Article
- Alterations in Rat Hippocampal Glutamatergic System Properties after Prolonged Febrile Seizures.International journal of molecular sciences · 2023Article
- Febrile Seizures Cause a Rapid Depletion of Calcium-Permeable AMPA Receptors at the Synapses of Principal Neurons in the Entorhinal Cortex and Hippocampus of the Rat.International journal of molecular sciences · 2023Article
- Ectopic expression of neuronal adenosine kinase, a biomarker in mesial temporal lobe epilepsy without hippocampal sclerosis.Neuropathology and applied neurobiology · 2023Article
- Status epilepticus and early development: Neuronal injury, neurodegeneration, and their consequences.Epilepsia open · 2023Review
- Xenon inhalation attenuates neuronal injury and prevents epilepsy in febrile seizure Sprague-Dawley pups.Frontiers in cellular neuroscience · 2023Article
- Prolonged Febrile Seizures Impair Synaptic Plasticity and Alter Developmental Pattern of Glial Fibrillary Acidic Protein (GFAP)-Immunoreactive Astrocytes in the Hippocampus of Young Rats.International journal of molecular sciences · 2022Article
- Early Life Febrile Seizures Impair Hippocampal Synaptic Plasticity in Young Rats.International journal of molecular sciences · 2021Article
- miR-135a-5p inhibitor protects glial cells against apoptosis via targeting SIRT1 in epilepsy.Experimental and therapeutic medicine · 2021Article
- Coordination of hippocampal theta and gamma oscillations relative to spatial active avoidance reflects cognitive outcome after febrile status epilepticus.Behavioral neuroscience · 2020Article
- Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy.Frontiers in aging neuroscience · 2020Article
- Developing a mouse model of acute encephalopathy using low-dose lipopolysaccharide injection and hyperthermia treatment.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- Treatment of early life status epilepticus: What can we learn from animal models?Epilepsia open · 2018Article
- Complex spectrum of phenobarbital effects in a mouse model of neonatal hypoxia-induced seizures.Scientific reports · 2018Article
- Neonatal Seizure Models to Study Epileptogenesis.Frontiers in pharmacology · 2018Review
- Early-life febrile seizures worsen adult phenotypes in Scn1a mutants.Experimental neurology · 2017Article
- Enduring Memory Impairments Provoked by Developmental Febrile Seizures Are Mediated by Functional and Structural Effects of Neuronal Restrictive Silencing Factor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Febrile seizures are the most common seizure type in young children. Whether they induce death of hippocampal and amygdala neurons and consequent limbic (temporal lobe) epilepsy has remained controversial, with conflicting data from prospective and retrospective studies. Using an appropriate-age rat model of febrile seizures, we investigated the acute and chronic effects of hyperthermic seizures on neuronal integrity and survival in the hippocampus and amygdala via molecular and neuroanatomical methods. Hyperthermic seizures-but not hyperthermia alone-resulted in numerous argyrophilic neurons in discrete regions of the limbic system; within 24 hr of seizures, a significant proportion of neurons in the central nucleus of the amygdala and in the hippocampal CA3 and CA1 pyramidal cell layer were affected. These physicochemical alterations of hippocampal and amygdala neurons persisted for at least 2 weeks but were not accompanied by significant DNA fragmentation, as determined by in situ end labeling. By 4 weeks after the seizures, no significant neuronal dropout in these regions was evident. In conclusion, in the immature rat model, hyperthermic seizures lead to profound, yet primarily transient alterations in neuronal structure.
Indexed as
Identifiers
9592105PMC3387924W2135251933What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.