ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
G protein-mediated inhibition of neuronal migration requires calcium influx.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Fasciclin 2 plays multiple roles in promoting cell migration within the developing nervous system of Manduca sexta.Developmental biology · 2023Article
- Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences.Frontiers in molecular neuroscience · 2017Review
- Amyloid Precursor Protein family as unconventional Go-coupled receptors and the control of neuronal motility.Neurogenesis (Austin, Tex.) · 2017Review
- Neuronal migration during development and the amyloid precursor protein.Current opinion in insect science · 2016Review
- Manduca Contactin Regulates Amyloid Precursor Protein-Dependent Neuronal Migration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- How does Reelin signaling regulate the neuronal cytoskeleton during migration?Neurogenesis (Austin, Tex.) · 2016Review
- Amyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development.Frontiers in molecular neuroscience · 2016Article
- Amyloid precursor proteins interact with the heterotrimeric G protein Go in the control of neuronal migration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug.Disease models & mechanisms · 2011Article
- Reverse signaling by glycosylphosphatidylinositol-linked Manduca ephrin requires a SRC family kinase to restrict neuronal migration in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA.American journal of physiology. Renal physiology · 2009Article
- Molecular mechanisms of go signaling.Neuro-Signals · 2009Review
- Reverse signaling via a glycosyl-phosphatidylinositol-linked ephrin prevents midline crossing by migratory neurons during embryonic development in Manduca.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- How to innervate a simple gut: familiar themes and unique aspects in the formation of the insect enteric nervous system.Developmental dynamics : an official publication of the American Association of Anatomists · 2007Review
- Eph receptor expression defines midline boundaries for ephrin-positive migratory neurons in the enteric nervous system of Manduca sexta.The Journal of comparative neurology · 2007Article
- The insect homologue of the amyloid precursor protein interacts with the heterotrimeric G protein Go alpha in an identified population of migratory neurons.Developmental biology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neuronal migration is an essential feature of the developing nervous system, but the intracellular signaling mechanisms that regulate this process are poorly understood. During the formation of the enteric nervous system (ENS) in the moth Manduca sexta, the migration of an identified set of neurons (the EP cells) is regulated in part by the heterotrimeric guanyl-nucleotide binding protein (G protein) Goalpha. Using an in vivo culture preparation for developing embryos that allows direct access to the ENS, we have shown that EP cell migration is similarly regulated by intracellular Ca2+; treatments that increased intracellular Ca2+ inhibited the migratory process, whereas buffering intracellular Ca2+ induced aberrant migration onto inappropriate pathways. Imaging the spontaneous changes in intracellular Ca2+ within individual EP cells showed that actively migrating neurons exhibited only small fluctuations in intracellular Ca2+. In contrast, neurons that had reached the end of migration displayed large, transient Ca2+ spikes. Similar Ca2+ spikes were induced in the EP cells by G protein stimulation, an effect that was reversed by removal of external Ca2+. Stimulation of Go in individual EP cells (by injection of either activated Goalpha subunits or mastoparan) also inhibited migration in a Ca2+-dependent manner. These results suggest that the regulation of neuronal migration by G proteins involves a Ca2+-dependent process requiring Ca2+ influx.
Indexed as
Identifiers
9592098PMC6792790W1583977712What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.