ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 106 citations in OpenAlex.
- Expanding the genetic and clinical landscapes of hereditary spastic paraplegia (HSP): a cohort study of 103 families.Orphanet journal of rare diseases · 2026Article
- Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro.Nature communications · 2022Article
- Genome-wide CRISPR screen identifies suppressors of endoplasmic reticulum stress-induced apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- REM obstructive sleep apnea: risk for adverse health outcomes and novel treatments.Sleep & breathing = Schlaf & Atmung · 2019Review
- A resource of potential drug targets and strategic decision-making for obstructive sleep apnoea pharmacotherapy.Respirology (Carlton, Vic.) · 2017Review
- Activation of the Hypoglossal to Tongue Musculature Motor Pathway by Remote Control.Scientific reports · 2017Article
- Fluid flow facilitates inward rectifier KScientific reports · 2016Article
- Inward rectifier potassium current (I K1) and Kir2 composition of the zebrafish (Danio rerio) heart.Pflugers Archiv : European journal of physiology · 2015Article
- Vascular inward rectifier K+ channels as external K+ sensors in the control of cerebral blood flow.Microcirculation (New York, N.Y. : 1994) · 2015Review
- The inward rectifier potassium channel Kir2.1 is expressed in mouse neutrophils from bone marrow and liver.American journal of physiology. Cell physiology · 2015Article
- A digital atlas of ion channel expression patterns in the two-week-old rat brain.Neuroinformatics · 2015Article
- State-dependent and reflex drives to the upper airway: basic physiology with clinical implications.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Review
- Identification of a pharmacological target for genioglossus reactivation throughout sleep.Sleep · 2014Article
- Role of methyl-induced polarization in ion binding.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Kir2.4 surface expression and basal current are affected by heterotrimeric G-proteins.The Journal of biological chemistry · 2013Article
- Inward-rectifying potassium (Kir) channels regulate pacemaker activity in spinal nociceptive circuits during early life.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Immunocytochemical localization of TASK-3 channels in rat motor neurons.Cellular and molecular neurobiology · 2012Article
- Cardiac strong inward rectifier potassium channels.Journal of molecular and cellular cardiology · 2010Review
- Cholesterol and Kir channels.IUBMB life · 2009Review
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Members of the Kir2 subfamily of inwardly rectifying K+ channels characterized by their strong current rectification are widely expressed both in the periphery and in the CNS in mammals. We have cloned from rat brain a fourth subfamily member, designated Kir2.4 (IRK4), which shares 53-63% similarity to Kir2.1, Kir2.2, or Kir2.3 on the amino acid level. In situ hybridization analysis identifies Kir2.4 as the most restricted of all Kir subunits in the brain. Kir2. 4 transcripts are expressed predominantly in motoneurons of cranial nerve motor nuclei within the general somatic and special visceral motor cell column and thus are uniquely related to a functional system. Heterologous expression of Kir2.4 in Xenopus oocytes and mammalian cells gives rise to low-conductance channels (15 pS), with an affinity to the channel blockers Ba2+ (Ki = 390 microM) and Cs+ (Ki = 8.06 mM) 30-50-fold lower than in other Kir channels. Low Ba2+ sensitivity allows dissection of Kir2.4 currents from other Kir conductances in hypoglossal motoneurons (HMs) in rat brainstem slices. The finding that Ba2+-mediated block of Kir2.4 in HMs evokes tonic activity and increases the frequency of induced spike discharge indicates that Kir2.4 channels are of major importance in controlling excitability of motoneurons in situ.
Indexed as
Identifiers
9592090PMC6792806W1859154741What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.