Trial reportLipids1998
Effects of dietary marine oils and olive oil on fatty acid composition, platelet membrane fluidity, platelet responses, and serum lipids in healthy humans.
Trial report in Lipids, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 102 citations in OpenAlex.
- Platelet dysfunction reversal with cold-stored vs room temperature-stored platelet transfusions.Blood · 2024Trial
- Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia.World journal of gastroenterology · 2008Trial
- EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors.Lipids · 2003Trial
- Omega-3 vs. omega-6 lipid emulsions exert differential influence on neutrophils in septic shock patients: impact on plasma fatty acids and lipid mediator generation.Intensive care medicine · 2003Trial
- Mediterranean diet, but not red wine, is associated with beneficial changes in primary haemostasis.European journal of clinical nutrition · 2003Trial
- Trial
- Dietary intake of whale oil-containing ω-3 long-chain polyunsaturated fatty acids attenuates choroidal neovascularization in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Association of Platelet Membrane Fatty Acid Composition with Markers of Oxidative Stress in Healthy Men.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Regulation of platelet function and thrombosis by omega-3 and omega-6 polyunsaturated fatty acids.Prostaglandins & other lipid mediators · 2018Review
- Cold-pressed minke whale oil reduces circulating LDL/VLDL-cholesterol, lipid oxidation and atherogenesis in apolipoprotein E-deficient mice fed a Western-type diet for 13 weeks.Nutrition & metabolism · 2018Article
- Antioxidant and Anti-Inflammatory Activities in Extracts from Minke Whale (Mediators of inflammation · 2017Article
- Polyunsaturated fatty acid status in treated isovaleric acidemia patients.European journal of clinical nutrition · 2016Article
- Characterization of Shrimp Oil from Pandalus borealis by High Performance Liquid Chromatography and High Resolution Mass Spectrometry.Marine drugs · 2015Article
- Determination and structural elucidation of triacylglycerols in krill oil by chromatographic techniques.Lipids · 2014Article
- The emerging role of oxylipins in thrombosis and diabetes.Frontiers in pharmacology · 2014Review
- Dietary enrichment of apolipoprotein E-deficient mice with extra virgin olive oil in combination with seal oil inhibits atherogenesis.Lipids in health and disease · 2011Article
- Article
- Article
- Habitual fish intake is associated with decreased LDL susceptibility to ex vivo oxidation.Lipids · 2002Article
- Incorporation of alpha-tocopherol in marine lipid-based liposomes: in vitro and in vivo studies.Lipids · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influence of various dietary marine oils and olive oil on fatty acid composition of serum and platelets and effects on platelets and serum lipids were investigated as part of an extensive study of the effects of these oils on parameters associated with cardiovascular/thrombotic diseases. Healthy volunteers (266) consumed 15 mL/d of cod liver oil (CLO); whale blubber oil (refined or unrefined); mixtures of seal blubber oil and CLO; or olive oil/CLO for 12 wk. In the CLO, seal oil/CLO, and whale oil groups, serum levels of eicosapentaenoic acid (EPA) were increased. In platelets, EPA was increased in the CLO, seal/CLO, and olive oil/CLO groups. The localization of n-3 polyunsaturated fatty acids in the triacylglycerols did not seem to influence their absorption. Intake of oleic acid is poorly reflected in serum and platelets. No significant differences in triacylglycerols (TG), total cholesterol, or high density lipoprotein cholesterol were observed, even though TG were reduced in the CLO, CLO/seal oil, and whale oil groups. Mean platelet volume increased significantly in both whale oil groups and the CLO/olive oil group. Platelet count was significantly reduced in the refined whale oil group only. Lipopolysaccharide-stimulated blood tended to generate less thromboxane B2 in CLO, CLO/seal, and CLO/olive groups. The whale oils tended to reduce in vivo release of beta-thromboglobulin. In conclusion, intake of various marine oils causes changes in platelet membranes that are favorably antithrombotic. The combination of CLO and olive oil may produce better effects than these oils given separately. The changes in platelet function are directly associated with alterations of fatty acid composition in platelet membranes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.