ArticleDigestive diseases and sciences1998
Eosinophil activation in ulcerative colitis: studies on mucosal release and localization of eosinophil granule constituents.
Article in Digestive diseases and sciences, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 85 citations in OpenAlex.
- Steroids reduce local inflammatory mediator secretion and mucosal permeability in collagenous colitis patients.World journal of gastroenterology · 2006Trial
- Effects of sulfasalazine on biopsy mucosal pathologies and histological grading of patients with active ulcerative colitis.World journal of gastroenterology · 2005Trial
- Eosinophil-derived COX-2 protects against experimental colitis through the PGEbioRxiv : the preprint server for biology · 2025Article
- Dietary fiber is a critical determinant of pathologic ILC2 responses and intestinal inflammation.The Journal of experimental medicine · 2024Article
- Emerging functions of tissue-resident eosinophils.The Journal of experimental medicine · 2023Review
- Intestinal eosinophils, homeostasis and response to bacterial intrusion.Seminars in immunopathology · 2021Review
- Acetylcholinesterase Inhibitor Pyridostigmine Bromide Attenuates Gut Pathology and Bacterial Dysbiosis in a Murine Model of Ulcerative Colitis.Digestive diseases and sciences · 2020Article
- Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Clinical value of serum eosinophilic cationic protein assessment in children with inflammatory bowel disease.Archives of medical science : AMS · 2014Article
- CD14+CD33+ myeloid cell-CCL11-eosinophil signature in ulcerative colitis.Journal of leukocyte biology · 2013Article
- Innate immunity modulation by the IL-33/ST2 system in intestinal mucosa.BioMed research international · 2013Review
- Eosinophils in infection and intestinal immunity.Current opinion in gastroenterology · 2013Review
- Colonic eosinophilic inflammation in experimental colitis is mediated by Ly6C(high) CCR2(+) inflammatory monocyte/macrophage-derived CCL11.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Gastrointestinal eosinophils in health, disease and functional disorders.Nature reviews. Gastroenterology & hepatology · 2010Review
- Treatment with a novel chemokine-binding protein or eosinophil lineage-ablation protects mice from experimental colitis.The American journal of pathology · 2009Article
- Serologic investigations in children with inflammatory bowel disease and food allergy.Mediators of inflammation · 2009Article
- Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Fecal markers of inflammation used as surrogate markers for treatment outcome in relapsing inflammatory bowel disease.World journal of gastroenterology · 2008Article
- Antibody to eosinophil cationic protein suppresses dextran sulfate sodium-induced colitis in rats.World journal of gastroenterology · 2005Article
- Evaluation of mucosal eosinophils in the pediatric colon.Digestive diseases and sciences · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of eosinophil granulocytes (eosinophils) seems to contribute to the pathophysiology of several inflammatory conditions. This process was evaluated in 18 patients with ulcerative colitis and in 18 healthy controls using intraluminal segmental perfusion of the sigmoid colon and rectum and immunoanalysis for eosinophil cationic protein (ECP) in the perfusate. Immunohistochemistry for eosinophils and neutrophils was made in simultaneously taken biopsies and in biopsies from surgical specimens taken from additional 10 patients. The mucosal release of ECP was increased severalfold in patients with UC. The bowel biopsies demonstrated a lamina propria infiltrated with eosinophils. The degree of eosinophil activation/degranulation was related to the intensity of the inflammatory reaction. Activated eosinophils and extracellular deposits of ECP were, in particular, seen in crypt abscesses and in areas with damaged surface epithelium. Since ECP is highly cytotoxic, its release at the site of inflammatory bowel lesions might reflect a potential pathophysiological mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.