ArticleThe American journal of pathology1998
Reduction in amyloid A amyloid formation in apolipoprotein-E-deficient mice.
Article in The American journal of pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Cross interactions between Apolipoprotein E and amyloid proteins in neurodegenerative diseases.Computational and structural biotechnology journal · 2023Review
- Accelerated pre-senile systemic amyloidosis in PACAP knockout mice - a protective role of PACAP in age-related degenerative processes.The Journal of pathology · 2018Article
- Genetics of Alzheimer's disease in Caribbean Hispanic and African American populations.Biological psychiatry · 2014Review
- Proteomic analysis of highly prevalent amyloid A amyloidosis endemic to endangered island foxes.PloS one · 2014Article
- Use of genetic variation as biomarkers for mild cognitive impairment and progression of mild cognitive impairment to dementia.Journal of Alzheimer's disease : JAD · 2010Review
- Use of genetic variation as biomarkers for Alzheimer's disease.Annals of the New York Academy of Sciences · 2009Review
- Association of apolipoprotein J-positive beta-amyloid plaques with dystrophic neurites in Alzheimer's disease brain.Neurotoxicity research · 2005Article
- Inhibition of amyloid A amyloidogenesis in vivo and in tissue culture by 4-deoxy analogues of peracetylated 2-acetamido-2-deoxy-alpha- and beta-d-glucose: implications for the treatment of various amyloidoses.The American journal of pathology · 2004Article
- In vivo effects of ApoE and clusterin on amyloid-beta metabolism and neuropathology.Journal of molecular neuroscience : MN · 2004Review
- Inflammation-dependent cerebral deposition of serum amyloid a protein in a mouse model of amyloidosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Role of apoe/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy.Journal of molecular neuroscience : MN · 2001Review
- Sodium dodecyl sulfate-resistant complexes of Alzheimer's amyloid beta-peptide with the N-terminal, receptor binding domain of apolipoprotein E.Biophysical journal · 2000Article
- Apolipoprotein E includes a binding site which is recognized by several amyloidogenic polypeptides.The Biochemical journal · 2000Article
- A protein required for prion generation: [URE3] induction requires the Ras-regulated Mks1 protein.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Renal amyloidosis as a late complication of Crohn's disease: a case report and review of the literature from Japan.World journal of gastroenterology · 2000Article
- The pathogenesis of amyloidosis: understanding general principles.The American journal of pathology · 1998Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Apolipoproteins have been implicated in the formation of amyloid fibrils. Recent studies have demonstrated that apolipoprotein E (apoE), alone or in combination with apolipoprotein J (apoJ), and other lipoproteins appear to enhance deposition of amyloid fibrils both in systemic and cerebral amyloids, especially Alzheimer's disease (AD). ApoE enhanced the ability of the amyloid beta-protein (1-40) fragment (A beta) to form fibrils in vitro, with apoE4 promoting the greatest fibril formation. ApoE was found associated with both human and mouse amyloid A (AA) deposits. To define the role of apoE in vivo, we utilized mice lacking the apoE gene by gene targeting. We used the AA model in mice to characterize the function of the apoE protein in amyloid fibrillogenesis. ApoE-deficient mice exhibited a decrease in deposition of AA when compared with heterozygous mutant or wild-type animals. In addition, apoE-deficient mice that were injected with an adenovirus that expressed the human apoE3 gene had restored AA deposition and the apoE was associated with the AA fibrils. These results are agreement with the in vitro studies using the beta-peptide and suggest that apoE is not essential for amyloid fibrillogenesis but can promote the development of amyloid deposition.
Indexed as
Identifiers
9588907PMC1858574W83881960What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.