ArticleThe American journal of pathology1998
B-cell monoclonality precedes the development of gastric MALT lymphoma in Helicobacter pylori-associated chronic gastritis.
Article in The American journal of pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 107 citations in OpenAlex.
- Update on the pathogenesis and clinical management ofWorld journal of gastrointestinal pathophysiology · 2025Review
- Gut microbiota in cats with inflammatory bowel disease and low-grade intestinal T-cell lymphoma.Frontiers in microbiology · 2024Review
- Role of non-World journal of gastroenterology · 2023Review
- Clinical relevance of molecular aspects in extranodal marginal zone lymphoma: a critical appraisal.Therapeutic advances in medical oncology · 2023Review
- Novel Insights into Pathophysiology of Orbital Inflammatory Diseases and Progression to Orbital Lymphoma by Pathway Enrichment Analysis.Life (Basel, Switzerland) · 2022Article
- GITR Promotes the Polarization of TFH-Like Cells inFrontiers in immunology · 2021Article
- Primary plasmablastic plasmacytoma in the stomach of an immunocompetent adult: A case report.Medicine · 2019Article
- Influence of Intestinal Indigenous Microbiota on Intrafamilial Infection byFrontiers in immunology · 2018Article
- Role of Helicobacter pylori in gastric mucosa-associated lymphoid tissue lymphomas.World journal of gastroenterology · 2014Review
- Low Grade Gastric Mucosa-associated Lymphoid Tissue Lymphoma: Clinicopathological Factors Associated with Helicobacter pylori Eradication and Tumor Regression.Clinical endoscopy · 2011Article
- Two Atypical Cases of Nodular Gastritis: A Poorly Differentiated Gastric Adenocarcinoma and a Pseudo-Low Grade Gastric MALT Lymphoma.Gastroenterology research · 2010Article
- Nodular gastritis: an endoscopic indicator of Helicobacter Pylori infection.Digestive diseases and sciences · 2007Article
- Molecular pathogenesis of MALT lymphoma: two signaling pathways underlying the antiapoptotic effect of API2-MALT1 fusion protein.Leukemia · 2006Review
- Molecular analysis of B-cell clonality in Helicobacter pylori gastritis.Digestive diseases and sciences · 2005Article
- Nodular gastritis in adults is caused by Helicobacter pylori infection.Digestive diseases and sciences · 2003Article
- Molecular pathology of primary intraocular lymphoma.Transactions of the American Ophthalmological Society · 2003Article
- Chromosomal translocation t(11;18)(q21;q21) in gastrointestinal mucosa associated lymphoid tissue lymphoma.Journal of clinical pathology · 2003Review
- PELA microspheres loaded H. pylori lysates and their mucosal immune response.World journal of gastroenterology · 2002Article
- IgH PCR of zinc formalin-fixed, paraffin-embedded non-lymphomatous gastric samples produces artifactual "clonal" bands not observed in paired tissues unexposed to zinc formalin.The Journal of molecular diagnostics : JMD · 2002Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about the temporal changes in Helicobacter pylori density and B-cell clonality during the evolution from chronic gastritis to gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Biopsied specimens from 28 patients with chronic gastritis who developed gastric MALT lymphoma (group A) and from 24 similar patients who did not (group B) during an equivalent follow-up period (mean, 42 months) were retrospectively scored for histological features of MALT lymphoma (0 to 5) and H. pylori density (0 to 3). B-cell clonality was analyzed by polymerase chain reaction (PCR). During the observation period, the H. pylori density in group A decreased significantly in comparison with group B; the mean change in H. pylori density (final minus initial density) per 1000 days was -1.4 for group A and +0.2 for group B (P < 0.005). Monoclonality was detected more frequently in group A (79%) than in group B (21%; P < 0.005), and it preceded the histological evidence of malignant transformation in 64% of those patients who showed monoclonality in group A. These results suggest that H. pylori is thus more closely associated with the precursor or initial phase in the genesis of gastric MALT lymphoma than with the later phase, as its density decreases as the tumor progresses. The detection of B-cell monoclonality by PCR is thus of possible use for predicting the histological genesis of gastric lymphoma.
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9588895PMC1858568W1811778638What OpenQuestion holds
Registered trials
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