ArticleThe Journal of cell biology1998
Modulation of integrin activity is vital for morphogenesis.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 58 citations in OpenAlex.
- Picalm coordinates clathrin-mediated endocytosis and actin remodeling during myogenesis.Molecular metabolism · 2026Article
- Focal adhesion-mediated cell anchoring and migration: from in vitro to in vivo.Development (Cambridge, England) · 2022Article
- LanB1 Cooperates With Kon-Tiki During Embryonic Muscle Migration inFrontiers in cell and developmental biology · 2021Article
- Tip cells act as dynamic cellular anchors in the morphogenesis of looped renal tubules in Drosophila.Developmental cell · 2013Article
- Extracellular matrix is required for muscle differentiation in primary cell cultures of larval Mytilus trossulus (Mollusca: Bivalvia).Cytotechnology · 2013Article
- Zasp regulates integrin activation.Journal of cell science · 2012Article
- Integrins are required for cardioblast polarisation in Drosophila.BMC developmental biology · 2012Article
- Identification of integrin beta subunit mutations that alter affinity for extracellular matrix ligand.The Journal of biological chemistry · 2011Article
- PS integrins and laminins: key regulators of cell migration during Drosophila embryogenesis.PloS one · 2011Article
- Vestigial is required during late-stage muscle differentiation in Drosophila melanogaster embryos.Molecular biology of the cell · 2010Article
- Differences in regulation of Drosophila and vertebrate integrin affinity by talin.Molecular biology of the cell · 2008Article
- Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo.The Journal of experimental medicine · 2007Article
- Identification of integrin beta subunit mutations that alter heterodimer function in situ.Molecular biology of the cell · 2004Article
- Novel activating and inactivating mutations in the integrin beta1 subunit A domain.The Biochemical journal · 2004Article
- Genetic interaction between integrins and moleskin, a gene encoding a Drosophila homolog of importin-7.Genetics · 2002Article
- Evidence that distinct states of the integrin alpha6beta1 interact with laminin and an ADAM.The Journal of cell biology · 1999Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells can vary their adhesive properties by modulating the affinity of integrin receptors. The activation and inactivation of integrins by inside-out mechanisms acting on the cytoplasmic domains of the integrin subunits has been demonstrated in platelets, lymphocytes, and keratinocytes. We show that in the embryo, normal morphogenesis requires the alpha subunit cytoplasmic domain to control integrin adhesion at the right times and places. PS2 integrin (alphaPS2betaPS) adhesion is normally restricted to the muscle termini, where it is required for attaching the muscles to the ends of other muscles and to specialized epidermal cells. Replacing the wild-type alphaPS2 with mutant forms containing cytoplasmic domain deletions results in the rescue of the majority of defects associated with the absence of the alphaPS2 subunit, however, the mutant PS2 integrins are excessively active. Muscles containing these mutant integrins make extra muscle attachments at aberrant positions on the muscle surface, disrupting the muscle pattern and causing embryonic lethality. A gain- of-function phenotype is not observed in the visceral mesoderm, showing that regulation of integrin activity is tissue-specific. These results suggest that the alphaPS2 subunit cytoplasmic domain is required for inside-out regulation of integrin affinity, as has been seen with the integrin alphaIIbbeta3.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.