ArticleMolecular and cellular biology1998
The position and length of the steroid-dependent hypersensitive region in the mouse mammary tumor virus long terminal repeat are invariant despite multiple nucleosome B frames.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 56 citations in OpenAlex.
- Transcriptional Bursting and Co-bursting Regulation by Steroid Hormone Release Pattern and Transcription Factor Mobility.Molecular cell · 2019Article
- Dynamics of chromatin accessibility and long-range interactions in response to glucocorticoid pulsing.Genome research · 2015Article
- Distinctly different dynamics and kinetics of two steroid receptors at the same response elements in living cells.PloS one · 2014Article
- Overlapping chromatin-remodeling systems collaborate genome wide at dynamic chromatin transitions.Nature structural & molecular biology · 2014Article
- Impact of chromatin structure on PR signaling: transition from local to global analysis.Molecular and cellular endocrinology · 2012Review
- ELL facilitates RNA polymerase II pause site entry and release.Nature communications · 2012Article
- Control of nuclear receptor function by local chromatin structure.The FEBS journal · 2011Review
- DNA methylation status predicts cell type-specific enhancer activity.The EMBO journal · 2011Article
- Multiple distinct stimuli increase measured nucleosome occupancy around human promoters.PloS one · 2011Article
- Article
- Glucocorticoid receptor dynamics and gene regulation.Stress (Amsterdam, Netherlands) · 2009Review
- Kinetic complexity of the global response to glucocorticoid receptor action.Endocrinology · 2009Article
- Dynamic access of the glucocorticoid receptor to response elements in chromatin.The international journal of biochemistry & cell biology · 2009Review
- Visualizing chromatin dynamics in intact cells.Biochimica et biophysica acta · 2008Review
- Chromatin remodeling complexes interact dynamically with a glucocorticoid receptor-regulated promoter.Molecular biology of the cell · 2008Article
- Sequence-dependent variations associated with H2A/H2B depletion of nucleosomes.Biophysical journal · 2008Article
- Organization of chromatin and histone modifications at a transcription site.The Journal of cell biology · 2007Article
- Ligand-specific dynamics of the androgen receptor at its response element in living cells.Molecular and cellular biology · 2007Article
- Chromatin dynamics and the evolution of alternate promoter states.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Review
- Ligand-specific dynamics of the progesterone receptor in living cells and during chromatin remodeling in vitro.Molecular and cellular biology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stimulation of the mouse mammary tumor virus with steroids results in the generation of a DNase I-hypersensitive region (HSR) spanning the hormone responsive element (HRE) in the long terminal repeat. Restriction enzymes were used to characterize the accessibility of various sites within the HSR of mouse mammary tumor virus long terminal repeat-reporter constructions in four different cell lines. The glucocorticoid-dependent HSR was found to span minimally 187 bases, a stretch of DNA longer than that associated with histones in the core particle. Although the 5'-most receptor binding site within the HRE is downstream of -190, hypersensitive sites were found further upstream to at least -295. The relationship in the accessibility between pairs of sites in the vicinity of the HSR was further examined in one cell line by a two-enzyme restriction access assay. In the uninduced state, the accessibilities at these sites were found to be independent of each other. In contrast, when stimulated with hormone, the accessibilities at these sites were observed to become linked. That is, once a distinct promoter was activated, all of the sites within the HSR of that molecule became accessible. The HSR formed along an invariant stretch of DNA sequence despite the multiplicity of nucleosome frames in the nucleosome B region, where the HRE is located. The results indicate that the macroscopic length of the HSR does not arise from core length-remodeling events in molecules containing Nuc-B in alternative positions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.