ArticleMolecular and cellular biology1998
Optimal activation of an endogenous gene by HOX11 requires the NH2-terminal 50 amino acids.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Annelid Distal-less/Dlx duplications reveal varied post-duplication fates.BMC evolutionary biology · 2011Article
- Lentiviral fluorescent protein expression vectors for biotinylation proteomics.Methods in molecular biology (Clifton, N.J.) · 2011Article
- Phosphorylation of HOX11/TLX1 on Threonine-247 during mitosis modulates expression of cyclin B1.Molecular cancer · 2010Article
- TLX1 and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells.Molecular cancer · 2010Article
- Transcriptional activation by TLX1/HOX11 involves Gro/TLE corepressors.Biochemical and biophysical research communications · 2009Article
- The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells.Leukemia · 2006Article
- Selection of antibodies for intracellular function using a two-hybrid in vivo system.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- cDNA cloning and expression of rat homeobox gene, Hex, and functional characterization of the protein.The Biochemical journal · 1999Article
- The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development.Molecular and cellular biology · 1998Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The HOX11 homeobox gene was first identified through studies of the t(7;10) and t(10;14) chromosomal translocations of acute T-cell leukemia. In addition, analysis of Hox11-/- mice has demonstrated a critical role for this gene in murine spleen development. A possible mode of in vivo function for the HOX11 protein in these two situations is regulation of target genes following DNA binding via the homeodomain, but little is known about how HOX11 regulates transcription in vivo. By performing transcriptional studies in yeast and mammalian one-hybrid systems, a modular transcriptional transactivation region at the NH2 terminus of HOX11 has been functionally dissected from other parts of the protein. This NH2-terminal region includes the previously identified short conserved Hep motif, which itself activates transcription in one-hybrid assays. The importance of the NH2-terminal region for the function of HOX11 in vivo was assayed by activating a HOX11-dependent gene in NIH 3T3 cells. Activation of this gene was found to be dependent upon an intact homeodomain in HOX11, but maximal activation was obtained only when the NH2-terminal 50 amino acids of HOX11 was present, showing that this region of HOX11 is important for in vivo transcriptional control of a chromosomal target gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.