ArticleMolecular and cellular biology1998
Recruitment of octamer transcription factors to DNA by glucocorticoid receptor.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 99 citations in OpenAlex.
- RNA binding by the glucocorticoid receptor attenuates dexamethasone-induced gene activation.Scientific reports · 2023Article
- High expression of transcription factor POU2F1 confers improved survival on smokers with lung adenocarcinoma: a retrospective study of two cohorts.Translational lung cancer research · 2023Article
- Mifepristone Treatment Promotes Testicular Leydig Cell Tumor Progression in Transgenic Mice.Cancers · 2020Article
- Molecular mechanisms underlying mifepristone's agonistic action on ovarian cancer progression.EBioMedicine · 2019Article
- Antiviral activity of the mineralocorticoid receptor NR3C2 against Herpes simplex virus Type 1 (HSV-1) infection.Scientific reports · 2018Article
- POU2F1 over-expression correlates with poor prognoses and promotes cell growth and epithelial-to-mesenchymal transition in hepatocellular carcinoma.Oncotarget · 2017Article
- The Oct1 transcription factor and epithelial malignancies: Old protein learns new tricks.Biochimica et biophysica acta · 2016Review
- Epigenetic characterization of the growth hormone gene identifies SmcHD1 as a regulator of autosomal gene clusters.PloS one · 2014Article
- A TRIP230-retinoblastoma protein complex regulates hypoxia-inducible factor-1α-mediated transcription and cancer cell invasion.PloS one · 2014Article
- Exploring the transcription factor activity in high-throughput gene expression data using RLQ analysis.BMC bioinformatics · 2013Article
- Differential activity of interferon-α8 promoter is regulated by Oct-1 and a SNP that dictates prognosis of glioma.Oncoimmunology · 2012Article
- The androgen receptor and its use in biological assays: looking toward effect-based testing and its applications.Journal of analytical toxicology · 2011Review
- Androgen receptor signaling and mutations in prostate cancer.Asian journal of andrology · 2010Review
- Characterization of cis elements of the probasin promoter necessary for prostate-specific gene expression.The Prostate · 2010Article
- Bacillus anthracis lethal toxin represses MMTV promoter activity through transcription factors.Journal of molecular biology · 2009Article
- Adaptive variation regulates the expression of the human SGK1 gene in response to stress.PLoS genetics · 2009Article
- Progesterone receptor action in leiomyoma and endometrial cancer.Progress in molecular biology and translational science · 2009Review
- Article
- The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1.The Journal of biological chemistry · 2005Article
- Glucocorticoid receptor-dependent gene regulatory networks.PLoS genetics · 2005Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucocorticoid receptor (GR) and octamer transcription factors 1 and 2 (Oct-1/2) interact synergistically to activate the transcription of mouse mammary tumor virus and many cellular genes. Synergism correlates with cooperative DNA binding of the two factors in vitro. To examine the molecular basis for these cooperative interactions, we have studied the consequences of protein-protein binding between GR and Oct-1/2. We have determined that GR binds in solution to the octamer factor POU domain. Binding is mediated through an interface in the GR DNA binding domain that includes amino acids C500 and L501. In transfected mammalian cells, a transcriptionally inert wild-type but not an L501P GR peptide potentiated transcriptional activation by Oct-2 100-fold above the level that could be attained in the cell by expressing Oct-2 alone. Transcriptional activation correlated closely with a striking increase in the occupancy of octamer motifs adjacent to glucocorticoid response elements (GREs) on transiently transfected DNAs. Intriguingly, GR-Oct-1/2 binding was interrupted by the binding of GR to a GRE. We propose a model for transcriptional cooperativity in which GR-Oct-1/2 binding promotes an increase in the local concentration of octamer factors over glucocorticoid-responsive regulatory regions. These results reveal transcriptional cooperativity through a direct protein interaction between two sequence-specific transcription factors that is mediated in a way that is expected to restrict transcriptional effects to regulatory regions with DNA binding sites for both factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.