ArticleMolecular and cellular biology1998
A chimeric subunit of yeast transcription factor IIIC forms a subcomplex with tau95.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Structural and kinetic insights into tRNA promoter engagement by yeast general transcription factor TFIIIC.Nucleic acids research · 2025Article
- RNA polymerase III-specific general transcription factor IIIC contains a heterodimer resembling TFIIF Rap30/Rap74.Nucleic acids research · 2013Article
- Structural and functional characterization of a phosphatase domain within yeast general transcription factor IIIC.The Journal of biological chemistry · 2013Article
- Autoregulation of an RNA polymerase II promoter by the RNA polymerase III transcription factor III C (TF(III)C) complex.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Full repression of RNA polymerase III transcription requires interaction between two domains of its negative regulator Maf1.The Journal of biological chemistry · 2010Article
- Maf1 is involved in coupling carbon metabolism to RNA polymerase III transcription.Molecular and cellular biology · 2007Article
- Modulation of yeast genome expression in response to defective RNA polymerase III-dependent transcription.Molecular and cellular biology · 2005Article
- Multiple roles of the tau131 subunit of yeast transcription factor IIIC (TFIIIC) in TFIIIB assembly.Molecular and cellular biology · 2002Article
- A truncation mutant of the 95-kilodalton subunit of transcription factor IIIC reveals asymmetry in Ty3 integration.Molecular and cellular biology · 2001Article
- Maf1p, a negative effector of RNA polymerase III in Saccharomyces cerevisiae.Molecular and cellular biology · 2001Article
- Comparison of the RNA polymerase III transcription machinery in Schizosaccharomyces pombe, Saccharomyces cerevisiae and human.Nucleic acids research · 2001Review
- Survey and summary: transcription by RNA polymerases I and III.Nucleic acids research · 2000Review
- A subunit of yeast TFIIIC participates in the recruitment of TATA-binding protein.Molecular and cellular biology · 1999Article
- The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity.Molecular and cellular biology · 1999Article
- Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III.Molecular and cellular biology · 1999Article
- Minimization and complete loss of general transcription factor proteins in the intracellular parasiteTranscriptionArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The multisubunit yeast transcription factor IIIC (TFIIIC) is a multifunctional protein required for promoter recognition, transcription factor IIIB recruitment, and chromatin antirepression. We report the isolation and characterization of TFC7, an essential gene encoding the 55-kDa polypeptide, tau55, present in affinity-purified TFIIIC. tau55 is a chimeric protein generated by an ancient chromosomal rearrangement. Its C-terminal half is essential for cell viability and sufficient to ensure TFIIIC function in DNA binding and transcription assays. The N-terminal half is nonessential and highly similar to a putative yeast protein encoded on another chromosome and to a cyanobacterial protein of unknown function. Partial deletions of the N-terminal domain impaired tau55 function at a high temperature or in media containing glycerol or ethanol, suggesting a link between PolIII transcription and metabolic pathways. Interestingly, tau55 was found, together with TFIIIC subunit tau95, in a protein complex which was distinct from TFIIIC and which may play a role in the regulation of PolIII transcription, possibly in relation to cell metabolism.
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