ArticleGenetics1998
Genetic identification of multiple loci that control breast cancer susceptibility in the rat.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 87 citations in OpenAlex.
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- Chemical carcinogen-induced rat mammary carcinogenesis is a potential model of p21-activated kinase positive female breast cancer.Physiological genomics · 2021Article
- Mapping Mammary Tumor Traits in the Rat.Methods in molecular biology (Clifton, N.J.) · 2019Review
- Model organism data evolving in support of translational medicine.Lab animal · 2018Review
- Physical Confirmation and Comparative Genomics of the RatG3 (Bethesda, Md.) · 2017Article
- Validation of six genetic determinants of susceptibility to estrogen-induced mammary cancer in the rat and assessment of their relevance to breast cancer risk in humans.G3 (Bethesda, Md.) · 2014Article
- Significant overlap between human genome-wide association-study nominated breast cancer risk alleles and rat mammary cancer susceptibility loci.Breast cancer research : BCR · 2014Article
- The gene desert mammary carcinoma susceptibility locus Mcs1a regulates Nr2f1 modifying mammary epithelial cell differentiation and proliferation.PLoS genetics · 2013Article
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- Multiple susceptibility loci for radiation-induced mammary tumorigenesis in F2[Dahl S x R]-intercross rats.PloS one · 2013Article
- Physical confirmation and mapping of overlapping rat mammary carcinoma susceptibility QTLs, Mcs2 and Mcs6.PloS one · 2011Article
- Identification of novel carcinogen-mediated mammary tumor susceptibility loci in the rat using the chromosome substitution technique.Genes, chromosomes & cancer · 2010Article
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- A statistical model for testing the pleiotropic control of phenotypic plasticity for a count trait.Genetics · 2008Article
- Mammary cancer susceptibility: human genes and rodent models.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Review
- Mammary tumor modifiers in BALB/cJ mice heterozygous for p53.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- On the generalized poisson regression mixture model for mapping quantitative trait loci with count data.Genetics · 2006Article
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- Genetic identification of distinct loci controlling mammary tumor multiplicity, latency, and aggressiveness in the rat.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
We have used a rat model of induced mammary carcinomas in an effort to identify breast cancer susceptibility genes. Using genetic crosses between the carcinoma-resistant Copenhagen (COP) and carcinoma-sensitive Wistar-Furth rats, we have confirmed the identification of the Mcs1 locus that modulates tumor number. We have now also identified two additional loci, Mcs2 and Mcs3. These three loci map to chromosomes 2, 7, and 1, respectively, and interact additively to suppress mammary carcinoma development in the COP strain. They are responsible for a major portion of the tumor-resistant phenotype of the COP rat. No loss of heterozygosity was observed surrounding the three loci. A fourth COP locus, Mcs4, has also been identified on chromosome 8 and acts in contrast to increase the number of carcinomas. These results show that mammary carcinoma susceptibility in the COP rat is a polygenic trait. Interestingly, a polymorphism in the human genomic region homologous to the rat Mcs4 region is associated with an increased breast cancer risk in African-American women. The isolation of the Mcs genes may help elucidate novel mechanisms of carcinogenesis, provide information important for human breast cancer risk estimation, and also provide unique drug discovery targets for breast cancer prevention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.