ArticleGenetics1998
Molecular and behavioral analysis of four period mutants in Drosophila melanogaster encompassing extreme short, novel long, and unorthodox arrhythmic types.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 80 citations in OpenAlex.
- A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- PERIOD Phosphoclusters Control Temperature Compensation of theFrontiers in physiology · 2022Article
- Locomotor activity patterns in three spider species suggest relaxed selection on endogenous circadian period and novel features of chronotype.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- Light and Temperature Synchronizes Locomotor Activity in the Linden Bug,Frontiers in physiology · 2020Article
- The Circadian Clock Improves Fitness in the Fruit Fly,Frontiers in physiology · 2019Article
- NewFrontiers in physiology · 2019Article
- CRISPR/Cas9 Genome Editing Introduction and Optimization in the Non-model InsectFrontiers in physiology · 2019Article
- Systems and synthetic biology approaches in understanding biological oscillators.Quantitative biology (Beijing, China) · 2018Article
- An RNAi Screen To Identify Protein Phosphatases That Function Within the Drosophila Circadian Clock.G3 (Bethesda, Md.) · 2016Article
- Casein kinase 1 promotes synchrony of the circadian clock network.Molecular and cellular biology · 2014Article
- Histamine-HisCl1 receptor axis regulates wake-promoting signals in Drosophila melanogaster.PloS one · 2013Article
- Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects.Neurobiology of disease · 2011Article
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- Activating PER repressor through a DBT-directed phosphorylation switch.PLoS biology · 2008Article
- The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock.Genes & development · 2008Article
- Even a stopped clock tells the right time twice a day: circadian timekeeping in Drosophila.Pflugers Archiv : European journal of physiology · 2007Review
- Functional role of CREB-binding protein in the circadian clock system of Drosophila melanogaster.Molecular and cellular biology · 2007Article
- A proposal for robust temperature compensation of circadian rhythms.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Natural allelic variation in the temperature-compensation mechanisms of the Arabidopsis thaliana circadian clock.Genetics · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Of the mutationally defined rhythm genes in Drosophila melanogaster, period (per) has been studied the most. We have molecularly characterized three older per mutants-perT, perClk, and per04-along with a novel long-period one (perSLIH). Each mutant is the result of a single nucleotide change. perT, perClk, and perSLIH are accounted for by amino acid substitutions; per04 is altered at a splice site acceptor and causes aberrant splicing. perSLIH exhibits a long period of 27 hr in constant darkness and entrains to light/dark (L/D) cycles with a later-than-normal evening peak of locomotion. perSLIH males are more rhythmic than females. perSLIH's clock runs faster at higher temperatures and slower at lower ones, exhibiting a temperature-compensation defect opposite to that of perLong. The per-encoded protein (PER) in the perT mutant cycles in L/D with an earlier-than-normal peak; this peak in perSLIH is later than normal, and there was a slight difference in the PER timecourse of males vs. females. PER in per04 was undetectable. Two of these mutations, perSLIH and perClk, lie within regions of PER that have not been studied previously and may define important functional domains of this clock protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.