ArticleGenetics1998
Mutations synthetically lethal with cep1 target S. cerevisiae kinetochore components.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- An interdependent Cbf1-CCAN interaction stabilizes the budding yeast kinetochore.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- An interdependent Cbf1-CCAN interaction stabilizes the budding yeast kinetochore.bioRxiv : the preprint server for biology · 2026Article
- Humanized Saccharomyces cerevisiae provides a facile and effective tool to identify damaging human variants that cause exosomopathies.G3 (Bethesda, Md.) · 2025Article
- Genome-Wide Characterization of the RNA Exosome Complex in Relation to Growth, Development, and Pathogenicity of Fusarium graminearum.Microbiology spectrum · 2023Article
- Polo kinase recruitment via the constitutive centromere-associated network at the kinetochore elevates centromeric RNA.PLoS genetics · 2020Article
- The RNA exosome and RNA exosome-linked disease.RNA (New York, N.Y.) · 2018Review
- RRP41L, a putative core subunit of the exosome, plays an important role in seed germination and early seedling growth in Arabidopsis.Plant physiology · 2013Article
- The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4.The EMBO journal · 2011Article
- Core exosome-independent roles for Rrp6 in cell cycle progression.Molecular biology of the cell · 2009Article
- Altered dosage and mislocalization of histone H3 and Cse4p lead to chromosome loss in Saccharomyces cerevisiae.Genetics · 2008Article
- Genetic and genomic analysis of the AT-rich centromere DNA element II of Saccharomyces cerevisiae.Genetics · 2005Article
- The histone fold domain of Cse4 is sufficient for CEN targeting and propagation of active centromeres in budding yeast.Eukaryotic cell · 2004Article
- Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregation.Molecular and cellular biology · 2003Article
- Autoantibodies directed to novel components of the PM/Scl complex, the human exosome.Arthritis research · 2002Article
- Determination of the binding constants of the centromere protein Cbf1 to all 16 centromere DNAs of Saccharomyces cerevisiae.Nucleic acids research · 2001Article
- The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma.Arthritis research · 2001Review
- Functional genomics reveals a family of eukaryotic oxidation protection genes.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Interaction of yeast kinetochore proteins with centromere-protein/transcription factor Cbf1.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA.Molecular and cellular biology · 2000Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CP1 (encoded by CEP1) is a Saccharomyces cerevisiae chromatin protein that binds a DNA element conserved in centromeres and in the 5'-flanking DNA of methionine biosynthetic (MET) genes. Strains lacking CP1 are defective in chromosome segregation and MET gene transcription, leading to the hypothesis that CP1 plays a general role in assembling higher order chromatin structures at genomic sites where it is bound. A screen for mutations synthetically lethal with a cep1 null allele yielded five recessive csl (cep1 synthetic lethal) mutations, each defining a unique complementation group. Four of the five mutations synergistically increased the loss rate of marker chromosomes carrying a centromere lacking the CP1 binding site, suggesting that the cep1 synthetic lethality was due to chromosome segregation defects. Three of these four CSL genes were subsequently found to be known or imputed kinetochore genes: CEP3, NDC10, and CSE4. The fourth, CSL4, corresponded to ORF YNL232w on chromosome XIV, and was found to be essential. A human cDNA was identified that encoded a protein homologous to Csl4 and that complemented the csl4-1 mutation. The results are consistent with the view that the major cellular role of CP1 is to safeguard the biochemical integrity of the kinetochore.
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