ArticleGenetics1998
Yeast dom34 mutants are defective in multiple developmental pathways and exhibit decreased levels of polyribosomes.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- UGA4 and YBR062C Regulate Oxidative Stress Tolerance Under Heavy Metal Toxicity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- A Proteomic Study of the Effect of N-acetylcysteine on the Regulation of Early Pregnancy in Goats.Animals : an open access journal from MDPI · 2022Article
- PELO facilitates PLK1-induced the ubiquitination and degradation of Smad4 and promotes the progression of prostate cancer.Oncogene · 2022Article
- Rebirth of the translational machinery: The importance of recycling ribosomes.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022Article
- LISTERIN E3 Ubiquitin Ligase and Ribosome-Associated Quality Control (RQC) Mechanism.Molecular neurobiology · 2021Review
- A recessive gene pepy-1 encoding Pelota confers resistance to begomovirus isolates of PepYLCIV and PepYLCAV in Capsicum annuum.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Pelota-interacting G protein Hbs1 is required for spermatogenesis in Drosophila.Scientific reports · 2019Article
- Interactions between the mRNA and Rps3/uS3 at the entry tunnel of the ribosomal small subunit are important for no-go decay.PLoS genetics · 2018Article
- A Pelota-like gene regulates root development and defence responses in rice.Annals of botany · 2018Article
- Suppression of the pelo protein by Wolbachia and its effect on dengue virus in Aedes aegypti.PLoS neglected tropical diseases · 2018Article
- Article
- Dom34 Links Translation to Protein O-mannosylation.PLoS genetics · 2016Article
- The RNA surveillance complex Pelo-Hbs1 is required for transposon silencing in the Drosophila germline.EMBO reports · 2015Article
- pelo is required for high efficiency viral replication.PLoS pathogens · 2014Article
- Article
- Article
- Recent structural studies on Dom34/aPelota and Hbs1/aEF1α: important factors for solving general problems of ribosomal stall in translation.Biophysics (Nagoya-shi, Japan) · 2013Review
- Surveillance pathways rescuing eukaryotic ribosomes lost in translation.Nature reviews. Molecular cell biology · 2012Review
- Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes.The EMBO journal · 2011Article
- Why Dom34 stimulates growth of cells with defects of 40S ribosomal subunit biosynthesis.Molecular and cellular biology · 2010Article
Corrections and comments
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2 authors.
Funding
Abstract
The DOM34 gene of Saccharomyces cerevisiae is similar to genes found in diverse eukaryotes and archaebacteria. Analysis of dom34 strains shows that progression through the G1 phase of the cell cycle is delayed, mutant cells enter meiosis aberrantly, and their ability to form pseudohyphae is significantly diminisehd. RPS30A, which encodes ribosomal protein S30, was identified in a screen for high-copy suppressors of the dom34delta growth defect. dom34delta mutants display an altered polyribosome profile that is rescued by expression of RPS30A. Taken together, these data indicate that Dom34p functions in protein translation to promote G1 progression and differentiation. A Drosophila homolog of Dom34p, pelota, is required for the proper coordination of meiosis and spermatogenesis. Heterologous expression of pelota in dom34delata mutants restores wild-type growth and differentiation, suggesting conservation of function between the eukaryotic members of the gene family.
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Registered trials
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